文献类型：期刊文献

英文题名：Highly interconnected macroporous MBG/PLGA scaffolds with enhanced mechanical and biological properties via green foaming strategy

作者：Song, Chaobo[1];Zhang, Jiapeng[1];Li, Shuang[2];Yang, Shengbin[3];Lu, Eryi[2];Xi, Zhenhao[1];Cen, Lian[1];Zhao, Ling[1];Yuan, Weikang[1]

机构：[1]East China Univ Sci & Technol, Sch Chem Engn, State Key Lab Chem Engn, Shanghai 200237, Peoples R China;[2]Shanghai Jiao Tong Univ, Renji Hosp, Sch Med, Dept Stomatol, Shanghai 200127, Peoples R China;[3]Shanghai Jiao Tong Univ, Shanghai Peoples Hosp 9, Sch Med, Shanghai Key Lab Orthopaed Implant,Dept Orthopaed, 639 Zhizaoju Rd, Shanghai 200011, Peoples R China

年份：2021

卷号：29

起止页码：426

外文期刊名：CHINESE JOURNAL OF CHEMICAL ENGINEERING

收录：;EI(收录号：20210109726585);WOS:【SCI-EXPANDED(收录号:WOS:000636564100050)】；

基金：The authors appreciate the experimental support and suggestion from Department of Stomatology of Renji Hospital, and the discussion with Dr.Xun P from Flinders Institute for NanoScale Science & Technology at Flinders University. The authors are grateful to the National Natural Science Foundation of China (Grant No. 21676083), the Fundamental Research Funds for the Central Universities and 111 Project (Grant No. B20031).

语种：英文

外文关键词：Scaffold; Mesoporous bioactive glass; Supercritical carbon dioxide; Foaming; Poly(lactic-co-glycolic acid)

摘要：In this study, mesoporous bioactive glass particles (MBGs) are incorporated into poly(lactic-co-glycolic acid) (PLGA) to fabricate highly interconnected macroporous composite scaffolds with enhanced mechanical and biological properties via a developed supercritical carbon dioxide (scCO(2)) foaming method. Scaffolds show favorable highly interconnected and macroporous structure through a high foaming pressure and long venting time foaming strategy. Specifically, scaffolds with porosity from 73% to 85%, pore size from 120 mu m to 320 mu m and interconnectivity of over 95% are controllably fabricated at MBG content from 0 wt% to 20 wt%. In comparison with neat PLGA scaffolds, composite scaffolds perform improved strength (up to 1.5 folds) and Young's modulus (up to 3 folds). The interconnected macroporous structure is beneficial to the ingrowth of cells. More importantly, composite scaffolds also provide a more promising microenvironment for cellular proliferation and adhesion with the release of bioactive ions. Hopefully, MBG/PLGA scaffolds developed by the green foaming strategy in this work show promising morphological, mechanical and biological features for tissue regeneration. (C) 2020 The Chemical Industry and Engineering Society of China, and Chemical Industry Press Co., Ltd. All rights reserved.