文献类型：期刊文献

英文题名：Preparation of non-spherical vaterite CaCO3 particles by flash nano precipitation technique for targeted and extended drug delivery

作者：Dou, Jiahong[1];Zhao, Fang[1];Fan, Wenting[1];Chen, Zhonghang[1];Guo, Xuhong[1]

机构：[1]East China Univ Sci & Technol, State Key Lab Chem Engn, Shanghai 200237, Peoples R China

年份：2020

卷号：57

外文期刊名：JOURNAL OF DRUG DELIVERY SCIENCE AND TECHNOLOGY

收录：;WOS:【SCI-EXPANDED(收录号:WOS:000538406900016)】；

基金：We gratefully thank the financial support from National Natural Science Foundation of China (21808059, 51761135128 and 51773061).

语种：英文

外文关键词：Calcium carbonate; Flash nano precipitation; Vaterite; Extended drug release; Anticancer drug delivery

摘要：An ideal anticancer drug release system is designed to release drugs over a prolonged period while minimizing the initial burst to significantly reduce the side effects and the number of medications. In this study, CaCO3 particles (average diameter 800-1600 nm with PDI< 0.2) aiming at such controlled release system were successfully prepared via Flash Nano Precipitation technique. Hydroxypropyl methylcellulose and sodium dodecyl sulfate were both employed as additives for CaCO3 crystallization to promote the formation of vaterite and convex-disc-shaped CaCO3, and at the same time as stabilizers for CaCO3 particles to control particle growth and avoid particle agglomeration. By using the as-prepared vaterites, a satisfying drug loading capacity (similar to 0.1 mg drug/mg particle) was realized, and prolonged drug release was achieved with a low initial release (< 10% within 1 day at pH = 6.0) and approximately zero-order release kinetics before 36 h (R-2 > 0.97) or after 36 h (R-2 > 0.99). Besides, by changing the particle size, different drug release kinetics could be achieved while the high drug loading capacity and low initial release were both maintained. The vaterite particles prepared in this work could be a potential candidate drug carrier for extended drug release with minimized initial burst and a constant drug releasing rate.