文献类型：期刊文献

中文题名：Therapeutic strategies against bacterial biofilms

作者：Yufang Bi[1];Guixue Xia[2];Chao Shi[2];Jianglin Wan[2];Longqiang Liu[2];Yuan Chen[2];Yueming Wu[2];Wenjing Zhang[2];Min Zhou[2];Hongyan He[2];Runhui Liu[1,2]

机构：[1]State Key Laboratory of Bioreactor Engineering,East China University of Science and Technology,Shanghai 200237,China;[2]Frontiers Science Center for Materiobiology and Dynamic Chemistry,Key Laboratory o f Specially Functional Polymeric Materials and Related Technology(ECUST)Ministry of Education,School of Materials Science and Engineering,East China University of Science and Technology,Shanghai 200237,China

年份：2021

卷号：1

期号：2

起止页码：193

中文期刊名：Fundamental Research

外文期刊名：自然科学基础研究（英文版）

基金：the Natural Science Foundation of Shanghai(18ZR1410300);the National Natural Science Foundation of China(No.21861162010,21774031,31800801);Program of Shanghai Academic/Technology Research Leader(20XD1421400);the National Key Research and Development Program of China(2016YFC1100401);Research Program of State Key Laboratory of Bioreactor Engineering;the Fundamental Research Funds for the Central Universities(No.22221818014,50321041917001)。

语种：英文

中文关键词：Antimicrobial resistance;Biofilm;Persister cell;Nanomaterials;Drug delivery

摘要：The emergence of multi-drug resistance makes bacterial infection a major threat to public health and economy.The formation of bacterial biofilms is one of the main reasons of bacterial resistance.The complexity of chemical composition and physical structure makes the elimination of mature biofilms a difficult problem.The highly antibiotic resistant property of biofilms urgently calls for potent antimicrobial agents and novel antibiofilm strategies.Researchers have made a lot of efforts in this field.Here we review the current strategies to eliminate mature biofilms and progress in related drug delivery nanosystems,with the aim of inspiring researchers to design new antibiofilm systems.