文献类型：期刊文献

英文题名：Kinetic and equilibrium study of the chromatographic separation of glycine and ammonium

作者：Jiang, Lihua[1]; Liu, Huiyuan[1]; Qiu, Yongjun[1]; Wang, Yaosong[1]; Chen, Chaoqin[1]; Wang, Qifan[2]; Zhao, Liming[1]

机构：[1] State Key Laboratory of Bioreactor Engineering, R&D Center of Separation and Extraction Technology in Fermentation Industry, East China University of Science and Technology, Shanghai, 200237, China; [2] College of Mechanical and Electrical Engineering, Beijing University of Chemical Technology, Beijing, 100029, China

年份：2014

卷号：1

期号：1

外文期刊名：Bioresources and Bioprocessing

收录：EI(收录号：20224513079109)

语种：英文

外文关键词：Amino acids - Column chromatography - Dispersions - Equilibrium constants - Liquid chromatography - Mass transfer - Separation

摘要：Background: Glycine is extensively applied in the field of food, medicine, agrochemistry, etc. It is usually commercially produced by the chemosynthesis method, which generates large amounts of by-product ammonium chloride. Methods: In this paper, the separation of glycine and ammonium chloride was performed with chromatographic column, and deionized water as eluent. The adsorption equilibrium constant K of glycine and ammonium chloride was evaluated by frontal analysis. Based on the equilibrium-dispersive model and a linear driving force of chromatography, the overall mass transfer coefficient km, axial dispersion coefficient DL, and bed voidage Εt of the column were obtained by moment analysis. Results: At 50°C, the equilibrium constants measured were found to be 0.72 and 0.19 for glycine and ammonium chloride, respectively. At 60°C, the equilibrium constants increased to 0.80 and 0.21 for glycine and ammonium chloride, respectively. The value of axial dispersion coefficient DL of glycine had the same order of magnitude with ammonium chloride and was about two times larger than that of ammonium chloride. Their km at 50°C and 60°C were 1.30 and 0.77 and 2.41 and 0.84 min?1 for glycine and ammonium chloride, respectively. Conclusions: The obtained parameters used to simulate the elution curve and the simulation and experimental results matched well, which showed that the parameters obtained were effective. The results make foundation for further study on large-scale separation of glycine from ammonium chloride by SMB chromatography. ? 2014 Jiang et al.