文献类型：期刊文献

英文题名：A Novel Droplet-Fabricated Mesoporous Silica-Based Nanohybrid Granules for Hemorrhage Control

作者：Zhou, Huayi[1,2,3];Wang, Chengwei[1,2];Niu, Haoyi[1,2];Duan, Bing[1,2];Ma, Xiaoyu[1,2];Hong, Hua[1,3];Yuan, Yuan[1,3];Liu, Changsheng[1,2]

机构：[1]East China Univ Sci & Technol, Key Lab Ultrafine Mat, Minist Educ, Shanghai 200237, Peoples R China;[2]East China Univ Sci & Technol, Minist Educ, Engn Res Ctr Biomat, Shanghai 200237, Peoples R China;[3]Shanghai Wego Biol Technol Co Ltd, Shanghai 200237, Peoples R China

年份：2018

卷号：14

期号：4

起止页码：649

外文期刊名：JOURNAL OF BIOMEDICAL NANOTECHNOLOGY

收录：;EI(收录号：20182205260653);WOS:【SCI-EXPANDED(收录号:WOS:000432853100003)】；

基金：The authors wish to express their gratitude to the financial supports from the National Natural Science Foundation of China for Innovative Research Groups (No. 51621002), the National Natural Science Foundation of China (No. 31330028), 111 Project (B14018), the Fundamental Research Funds for the Central Universities (222201718002) and Science and Technology Commission Shanghai Municipality (16441902800).

语种：英文

外文关键词：Hemostasis; Mesoporous Silica; Sodium Alginate; Multipore; Adhesive; Nanohybrid Granule

摘要：Uncontrolled hemorrhage is one of the leading cause for death in both civilian and military trauma. The zeolite-based hemostatic agent currently available in clinic exhibits great exothermic reaction and poor biodegradability. To overcome these limitations, in this study, we developed a novel mesoporous silica (MS)-based calcium alginate nanohybrid granule (p-MS/CA) for hemorrhage control. The p-MS/CA was prepared by an in situ pore-forming, droplet process and the granule prepared was 2-3 mm in size with rough and macroporous surface. The p-MS/CA could significantly accelerate water absorption and block off the damaged tissue, and thereby efficiently promoted platelet and plasma protein adhesion, enhanced wound adherence, facilitated the contact activation pathway of coagulation cascade with desirable hemostasis. Hemostasis test demonstrated that the p-MS/CA granule could reduce about 50% hemostatic time both in vitro and vivo and decrease blood loss. Meanwhile, the nanocomposite of p-MS/CA exhibited excellent cell viability and did not induce hemolysis. Furthermore, the preparation process for multipore p-MS/CA is low-cost, quick and easy to achieve large-scale production. Owing to the superior hemostatic performance and simple preparation process, we believe that this study will provide an alternative approach for hemorrhage control in some specific injury types, and have immense potential for commercial and clinical application.