文献类型：期刊文献

英文题名：One-Pot Synthesis of Fe-Norepinephrine Nanoparticles for Synergetic Thermal-Enhanced Chemodynamic Therapy

作者：Xiao, Yufen[1,2,3];Tang, Zhongmin[1,2];Zhang, Jiamin[3,4];Saiding, Qimanguli[1,2];Li, Yongjiang[1,2];Du, Jianzhong[3,4,5];Tao, Wei[1,2]

机构：[1]Harvard Med Sch, Brigham & Womens Hosp, Ctr Nanomed, Boston, MA 02115 USA;[2]Harvard Med Sch, Brigham & Womens Hosp, Dept Anesthesiol, Boston, MA 02115 USA;[3]Tongji Univ, Shanghai Peoples Hosp 4, Translat Res Inst Brain & Brain Intelligence, Shanghai Key Lab Anesthesiol & Brain Funct Modulat, Shanghai 200434, Peoples R China;[4]Tongji Univ, Sch Mat Sci & Engn, Dept Polymer Mat, Shanghai 201804, Peoples R China;[5]East China Univ Sci & Technol, Sch Mat Sci & Engn, Shanghai 200237, Peoples R China

年份：2024

卷号：24

期号：43

起止页码：13825

外文期刊名：NANO LETTERS

收录：;EI(收录号：20244217224559);WOS:【SCI-EXPANDED(收录号:WOS:001338224700001)】；

基金：W.T. acknowledges the support from the American Lung Association (ALA) Cancer Discovery Award (No. LCD1034625), ALA Courtney Cox Cole Lung Cancer Research Award (No. 2022A017206), Harvard Medical School/Brigham and Women's Hospital Health & Technology Innovation Fund (No. 2023A004452), Nanotechnology Foundation (No. 2022A002721), and Distinguished Chair Professorship Foundation (No. 018129). J.D. appreciates the support from National Natural Science Foundation of China (21925505 and 22335005) and Innovation Program of Shanghai Municipal Education Commission (2023ZKZD28). The TOC Graphic was created with BioRender.com.

语种：英文

外文关键词：chemodynamic therapy (CDT); photothermal therapy (PTT); coordination chemistry; Fenton reaction; synergistictherapy

摘要：Chemodynamic therapy (CDT) is an innovative and burgeoning strategy that utilizes Fenton-Fenton-like chemistry and specific microenvironments to produce highly toxic hydroxyl radicals (center dot OH), with numerous methods emerging to refine this approach. Herein, we report a coordination compound, Fe-norepinephrine nanoparticles (Fe-NE NPs), via a one-pot synthesis. The Fe-NE NPs are based on ferrous ions (Fe2+) and norepinephrine, which are capable of efficient Fe2+/Fe3+ delivery. Once internalized by tumor cells, the released Fe2+/Fe3+ exerts the Fenton reaction to specifically produce toxic center dot OH. Moreover, the internal photothermal conversion ability of Fe-NE NPs allows us to simultaneously introduce light to trigger local heat generation and then largely improve the Fenton reaction efficiency, which enables a synergetic photothermal and chemodynamic therapy to realize satisfactory in vivo antitumor efficiency. This proof-of-concept work offers a promising approach to developing nanomaterials and refining strategies for enhanced CDT against tumors.