文献类型：期刊文献

中文题名：CO_2辅助膨胀制备微细PCL颗粒

英文题名：Micronization of PCL by Supercritical Carbon Dioxide Assisted Expansion

作者：杨雷[1];蔡建国[1];杨锋[1]

机构：[1]华东理工大学化学工程研究所,上海200237

年份：2010

卷号：26

期号：1

起止页码：129

中文期刊名：高分子材料科学与工程

外文期刊名：Polymer Materials Science & Engineering

收录：CSTPCD;;EI(收录号：20101212786680);Scopus;北大核心:【北大核心2008】；CSCD:【CSCD2011_2012】；

语种：中文

中文关键词：超临界CO2;同轴喷嘴;微粒制备;聚己酸内酯

外文关键词：supercritical carbon dioxide; coaxial nozzle; microparticle formation; polycaprolactone

摘要：采用超临界CO_2辅助膨胀结合喷嘴雾化分散过程,制备可用于药物缓控释制剂材料聚己酸内酯微细颗粒。实验考察了聚己酸内酯-二氯己烷溶液浓度、流量、预膨胀温度、顸膨胀压力对颗粒尺寸和形貌的影响。结果表明,增加预膨胀压力、降低预膨胀温度、减小喷嘴孔径能得到聚己内酯微细颗粒;在一定的溶液初始浓度、溶液流率范围内,较高的溶液初始浓度、较高的溶液流率,可得到小于1μm聚己酸内酯微细球状颗粒。
Polycaprolactone （PCL） is a polymeric material that is used in controlled release medicine or as a drug carrier, and the microparticle formation of PCL is studied using supercritical carbon dioxide assisted expansion technology with a custom-made special nozzle. The influences of concentration of＇ PCL- dichloromethane solution, molar flux, and the pre-expansion temperature and pressure were discussed. Scanning electronic microscope （SEM） photos show that mean particle size （MPS） of PCL produced by supereritical carbon dioxide assisted expansion is less than 1 μm, which can be obtained within certain concentration and molar flux of PCL. And higher pre-expansion pressure, lower pre-expansion temperature, smaller the diameter of nozzle are favorable for narrow particles size distribution.