文献类型：期刊文献

英文题名：The Reaction of Aryl Thiols or Thioureas with o-Diiodoarenes/NaH to Access o-Iodoaryl Thioethers

作者：Hu, Min[1,2,6];Liu, Dianfan[1,2,6];Liu, Yuan[1,2];Luo, Fan[3];Chen, Xiaobei[4,5];Yin, Yuejia[1,2];Zhang, Shilei[1,2,6];Hu, Yanwei[1,2,6]

机构：[1]Soochow Univ, Jiangsu Key Lab Neuropsychiat Dis, 199 Renai Rd, Suzhou 215123, Jiangsu, Peoples R China;[2]Soochow Univ, Coll Pharmaceut Sci, 199 Renai Rd, Suzhou 215123, Jiangsu, Peoples R China;[3]Jiaxing Univ, Coll Med, 118 Jiahang Rd, Jiaxing 314001, Peoples R China;[4]East China Univ Sci & Technol, Sch Pharm, State Key Lab Bioreactor Engn, Shanghai 200237, Peoples R China;[5]East China Univ Sci & Technol, Sch Pharm, Shanghai Key Lab New Drug Design, Shanghai 200237, Peoples R China;[6]Soochow Univ, Jiangsu Prov Engn Res Ctr Precis Diagnost & Therap, Suzhou 215123, Peoples R China

年份：2024

卷号：366

期号：7

起止页码：1538

外文期刊名：ADVANCED SYNTHESIS & CATALYSIS

收录：;WOS:【SCI-EXPANDED(收录号:WOS:001176724800001)，CCR-EXPANDED(收录号:WOS:001176724800001)】；

基金：This work was supported by National Natural Science Foundation of China (22271206 and 22071053), Suzhou International Joint Laboratory for Diagnosis and Treatment of Brain Diseases, East China University of Science and Technology (the '111' Project) and PAPD (A Project Funded by the Priority Academic Program Development of Jiangsu Higher Education Institutions).

语种：英文

外文关键词：o-Iodoaryl thioether; Aryne; o-Diiodoarene; Sodium hydride; Arylation

摘要：Herein we report a method for the synthesis of thioethers by forging C(aryl)-S bond via an aryne mechanism. The active aryne species can be generated from o-diiodoarenes and NaH in THF at room temperature, then lead to the arylations of a wide range of aryl thiols and thioureas. Different from transition metal-catalyzed cross-coupling reactions, no disubstituted byproduct is formed in our protocol. The o-iodoaryl thioether products are intermediates that could be transformed into pharmaceutically interesting molecules.