文献类型：期刊文献

英文题名：One-pot sequential asymmetric hydrogenation of β-aryl-β-aryloxy acroleins

作者：Liu, Yufeng[1];Chen, Jianzhong[2];Zhang, Zhenfeng[3];Qin, Jian[1];Zhao, Min[1];Zhang, Wanbin[2,3]

机构：[1]East China Univ Sci & Technol, Sch Chem & Mol Engn, 130 Meilong Rd, Shanghai 200237, Peoples R China;[2]Shanghai Jiao Tong Univ, Sch Chem & Chem Engn, 800 Dongchuan Rd, Shanghai 200240, Peoples R China;[3]Shanghai Jiao Tong Univ, Sch Pharm, 800 Dongchuan Rd, Shanghai 200240, Peoples R China

年份：2016

卷号：14

期号：29

起止页码：7099

外文期刊名：ORGANIC & BIOMOLECULAR CHEMISTRY

收录：;EI(收录号：20163102654256);WOS:【SCI-EXPANDED(收录号:WOS:000380338000027)，CCR-EXPANDED(收录号:WOS:000380338000027)】；

基金：This work was partially supported by the National Natural Science Foundation of China (no. 21232004, 21472123, and 21572131), the Science and Technology Commission of Shanghai Municipality (no. 14XD1402300) and the China Post-doctoral Science Foundation (no. 2014M551397). We thank the Instrumental Analysis Center of Shanghai Jiao Tong University (SJTU) for the characterization.

语种：英文

外文关键词：Aldehydes - Hydrogenation

摘要：A one-pot sequential asymmetric hydrogenation of beta-aryl-beta-aryloxy acroleins has been realized for the preparation of chiral 3-aryl-3-aryloxy alcohols with excellent yields and good enantioselectivities. This methodology can be employed in new synthetic routes for the synthesis of fluoxetine, atomoxetine, and related analogues.