文献类型：期刊文献

英文题名：The discovery of new scaffold of plant activators: From salicylic acid to benzotriazole

作者：Chang, Kang[1];Chen, Jian-Qin[1];Shi, Yan-Xia[3];Sun, Mei-Jian[2];Li, Peng-Fei[1];Zhao, Zhen-Jiang[2];Zhu, Wei-Ping[1];Li, Hong-Lin[2];Xu, Yu-Fang[1];Li, Bao-Ju[3];Qian, Xu-Hong[1]

机构：[1]East China Univ Sci & Technol, Shanghai Key Lab Chem Biol, Sch Pharm, State Key Lab Bioreactor Engn, Shanghai 200237, Peoples R China;[2]East China Univ Sci & Technol, Shanghai Key Lab New Drug Design, Sch Pharm, State Key Lab Bioreactor Engn, Shanghai 200237, Peoples R China;[3]Chinese Acad Agr Sci, Inst Vegetables & Flowers, Beijing 100081, Peoples R China

年份：2017

卷号：28

期号：4

起止页码：919

外文期刊名：CHINESE CHEMICAL LETTERS

收录：;WOS:【SCI-EXPANDED(收录号:WOS:000402214400038)】；

基金：This work was financially supported by the National Basic Research Program of China (973 Program, No. 2010CB126100), the National High Technology Research and Development Program of China (863 Program, No. 2011AA10A207), the Shanghai Leading Academic Discipline Project (B507), and the Fundamental Research Funds for the Central Universities.

语种：英文

外文关键词：Plant activator; Systemic acquired resistance; Salicylic acid; Benzotriazole; Virtual screening

摘要：Started from salicylic acid (SA) and related commercialized plant activators, based on molecular three-dimensional shape and pharmacophore similarity comparison (SHAFTS), a new lead compound benzotriazole was predicted and a series of benzotriazole derivatives were designed and synthesized. The bioassay showed that benzotriazole had high activity against a broad spectrum of diseases including fungi and oomycetes in vivo, but no activity in vitro. And the introduction of proper groups at the 1'-position and 5'-position was beneficial to the activity. So, they had the potential to be exploited as novel plant activators. (C) 2017 Chinese Chemical Society and Institute of Materia Medica, Chinese Academy of Medical Sciences. Published by Elsevier B.V. All rights reserved.