文献类型：期刊文献

英文题名：An integrated experimental-numerical strategy for crystal size regulation in a continuous non-isothermal Couette-Taylor crystallizer

作者：Li, Qiang[1];Li, Yunpeng[1];Chen, Weitong[1];Zhang, Xiangyang[1]

机构：[1]East China Univ Sci & Technol, State Key Lab Chem Engn, Shanghai 200237, Peoples R China

年份：2026

卷号：335

外文期刊名：CHEMICAL ENGINEERING SCIENCE

收录：;EI(收录号：20262420875890);WOS:【SCI-EXPANDED(收录号:WOS:001797947400001)】；

基金：This research received financial support from the Natural Science Foundation of Shanghai Municipality (No. 23ZR1417100) .

语种：英文

外文关键词：Continuouscrystallization; Couette-Taylor crystallizer; Integrated experimental-numerical strategy; Population balancemodeling; Crystal size distribution (CSD)

摘要：Couette-Taylor crystallizers (CTCs) exhibit significant potential for precise crystal size control in continuous crystallization, attributed to their tunable flow patterns, residence time distributions (RTD), and supersaturation fields. However, the complex interaction between thermo-fluid dynamics and crystallization kinetics within the crystallizer complicates the quantitative correlation between operating conditions and crystal size, thereby hindering industrial implementation. This study proposes an integrated experimental-numerical strategy based on a one-way sequential coupling framework to establish a systematic development path for crystal size regulation during non-isothermal cooling crystallization within the CTC. By combining flow characterization, thermal field analysis, crystallization experiments, and population balance modeling (PBM), a quantitative correlation between operating parameters and product size was established. The results demonstrate that the proposed strategy enables stable size tuning across various conditions (d50 = 86.8-331.1 mu m) with high product uniformity (typically CV <= 0.35), with PBM predictions showing good agreement with experimental values. Furthermore, cross-system validation and long-term continuous operation confirm the scalability and robustness of this approach. This research establishes a controllability-oriented design framework for crystal size tuning in continuous pharmaceutical manufacturing.