文献类型：期刊文献

英文题名：Sterically Controlled Cu-Catalyzed or Transition-Metal-Free Cross-Coupling of gem-Difluoroalkenes with Tertiary, Secondary, and Primary Alkyl Grignard Reagents

作者：Dai, Wenpeng[1];Shi, Hongyan[1];Zhao, Xianghu[1];Cao, Song[1]

机构：[1]East China Univ Sci & Technol, Sch Pharm, Shanghai Key Lab Chem Biol, Shanghai 200237, Peoples R China

年份：2016

卷号：18

期号：17

起止页码：4284

外文期刊名：ORGANIC LETTERS

收录：;WOS:【SCI-EXPANDED(收录号:WOS:000382711200035)，CCR-EXPANDED(收录号:WOS:000382711200035)】；

基金：We are grateful for financial support from the National Natural Science Foundation of China (Nos. 21472043 and 21272070).

语种：英文

摘要：A robust copper-catalyzed or transition-metal-free cross-coupling of gem-difluoroalkenes with tertiary, secondary, and primary alkyl Grignard reagents has been developed. Remarkably, the tertiary and secondary alkylation of gem-difluoroalkenes proceeded very smoothly in the presence of 2S mol % of CuCN or under transition-metal-free conditions, affording the tertiary and secondary alkyl-substituted fluoroalkenes in good to excellent yields with excellent Z stereoselectivity.