文献类型：期刊文献

英文题名：A practical ligand-free copper(I) bromide-catalyzed fluoroalkoxylation of unactivated aryl bromides

作者：Guo, Ying[1];Li, Yu-Dao[1];Chen, Cheng[1];Zhao, Jian-Hong[1];Liu, Hong-Wei[1];Liao, Dao-Hua[1];Ji, Ya-Fei[1]

机构：[1]E China Univ Sci & Technol, Sch Pharm, Shanghai 200237, Peoples R China

年份：2016

卷号：42

期号：3

起止页码：2525

外文期刊名：RESEARCH ON CHEMICAL INTERMEDIATES

收录：;EI(收录号：20152901035933);WOS:【SCI-EXPANDED(收录号:WOS:000372031300063)，CCR-EXPANDED(收录号:WOS:000372031300063)】；

基金：The authors are grateful to the National Natural Science Foundation of China (Project Nos. 21176074 and 21476074), and the Research Fund for the Doctoral Program of Higher Education of China (Project No. 20130074110009) for financial support.

语种：英文

外文关键词：Fluoroalkoxylation; Ligand-free catalysis; Unactivated aryl bromides; Copper(I) bromide; Aryl fluoroalkyl ethers

摘要：An efficient ligand-free fluoroalkoxylation of unactivated aryl bromides has been developed, with special attention focused on practicability of the reaction. Without precious metal and organic ligand, the reaction was carried out under the catalytic system of inexpensive copper(I) bromide as a catalyst, N,N-dimethyl formamide as a cocatalyst, and the corresponding stoichiometric sodium fluoroalkoxide as a nucleophilic reagent. The facile approach avoids the drawbacks associated with cost, separation and pollution of ligand to enable sustainable access to aryl fluoroalkyl ethers from readily available bromoarenes.