文献类型：期刊文献

英文题名：NiHCF@PDAP-Enhanced Wearable Microneedle Biosensor for Continuous and Lifetime-Prolonged Monitoring of Uric Acid in Interstitial Fluid

作者：Sun, Hongyi[1];Wang, Shidi[1];Zhu, Anwei[1];Wang, Tao[2];Wang, Haoxin[3];Zheng, Youbin[4];Shi, Guoyue[1];Zhang, Min[1]

机构：[1]East China Normal Univ, In Situ Devices Res Ctr, Sch Chem & Mol Engn, Shanghai 200241, Peoples R China;[2]East China Univ Sci & Technol, Sch Mech & Power Engn, Shanghai Key Lab Intelligent Sensing & Detect Tech, Shanghai 200237, Peoples R China;[3]RMIT Univ, STEM Coll, Sch Sci, Melbourne 3083, Australia;[4]Univ Liverpool, Dept Elect Engn & Elect, Liverpool L69 3GJ, England

年份：2025

卷号：10

期号：7

起止页码：4906

外文期刊名：ACS SENSORS

收录：;EI(收录号：20255119734002);WOS:【SCI-EXPANDED(收录号:WOS:001530058800001)】；

基金：This work was supported by the National Natural Science Foundation of China (22274053, 22274051, 62301314, and 52321002), the Science and Technology Commission of Shanghai Municipality (24140711700).

语种：英文

外文关键词：wearable; microneedle; ISF; long-termmonitoring; flexibility; UA

摘要：Personalized healthcare requires convenient and high-fidelity approaches to monitoring metabolic biomarkers, for example, uric acid (UA), toward next-generation disease management. Although wearable microneedle-based devices stand out with miniaturized needle-like sensors capable of transdermal monitoring of UA in interstitial fluid (ISF) in an imperceptible manner, their rigid nature and limited lifespan pose considerable challenge to the practicability as continuous biosensors in real-world application. Here, we present a wearable microneedle-based biosensor that integrates the strength of microneedle with a Prussian Blue analog, that is, nickel hexacyanoferrate, enhanced sensing interface to minimally invasive access UA in ISF and enable highly blood-correlated, continuous, and long-term monitoring. By incorporating conductive poly(2,6-diaminopyridine), the as-proposed microneedle biosensor renders highly sensitive monitoring of UA with a detection limit of 1.78 mu M. In addition, the fully integrated device features prominent mechanical resilience and flexibility against undesirable physical deformations, ensuring reliable sensing performance of UA in daily activities. In animal models, the resulting biosensors achieved dynamic UA tracking with excellent stability and captured prolonged amperometric information interpreting the metabolic changes of UA levels during a seven-week in vivo experiment. The strong correlation between the obtained ISF and blood UA levels demonstrated the high analytical accuracy of the biosensor, which, thus, provided a powerful approach to fulfill personalized UA management in the future.