文献类型：期刊文献

英文题名：Synthesis of N,N-disubstituted 2-aminothiophenes by the cyclization of gem-difluoroalkenes with β-keto thioamides

作者：Zhang, Xuxue[1];Wu, Mingsheng[1];Zhang, Juan[1];Cao, Song[1,2]

机构：[1]East China Univ Sci & Technol, Sch Pharm, Shanghai Key Lab Chem Biol, Shanghai 200237, Peoples R China;[2]Chinese Acad Sci, Shanghai Inst Organ Chem, Key Lab Organofluorine Chem, Shanghai 200032, Peoples R China

年份：2017

卷号：15

期号：11

起止页码：2436

外文期刊名：ORGANIC & BIOMOLECULAR CHEMISTRY

收录：;EI(收录号：20171203458389);WOS:【SCI-EXPANDED(收录号:WOS:000397945900017)，CCR-EXPANDED(收录号:WOS:000397945900017)】；

基金：We are grateful for financial support from the National Natural Science Foundation of China (Grant No. 21472043 and 21272070).

语种：英文

外文关键词：Potash - Transition metals

摘要：A novel and effective method for the construction of highly functionalized aminothiophenes via the cyclization of gem-difluoroalkenes with beta-keto tertiary thioamides is described. The reactions proceed smoothly with the assistance of K2CO3 under transition-metal-free conditions, affording a variety of valuable N, N-disubstituted 2-aminothiophenes in moderate to good yields.