文献类型：期刊文献

英文题名：Dual-targeting magnetic fluorescent mesoporous organosilicon hollow nanospheres for gambogic acid loading, sustained release and anti-tumor properties

作者：Chang, Ziling[1];Yang, Yuxiang[1];Zhao, Bo[2];Li, Huafei;Guan, Yuxia;Zhao, Yi[1];Yuan, Hongming[4];Ni, Chaoying[3]

机构：[1]East China Univ Sci & Technol, Sch Chem & Mol Engn, Shanghai 200237, Peoples R China;[2]Second Mil Med Univ, Changhai Hosp, Dept Nucl Med, Shanghai 200237, Peoples R China;[3]Univ Delaware, Dept Mat Sci & Engn, Newark, DE 19716 USA;[4]Jilin Univ, State Key Lab Inorgan Synth & Preparat Chem, Changchun 130012, Peoples R China; Shanghai Univ, Sch Life Sci, 333 Nanchen Rd, Shanghai, Peoples R China

年份：2022

卷号：360

外文期刊名：JOURNAL OF MOLECULAR LIQUIDS

收录：;EI(收录号：20222312189219);WOS:【SCI-EXPANDED(收录号:WOS:000808000100004)】；

基金：This work was supported by the National Natural Science Foun-dation of China (20577010, 20971043) , and the Open Project Pro-gram of State Key Laboratory of Inorganic Synthesis and Preparative Chemistry, Jilin University.

语种：英文

外文关键词：Nano drug delivery system; Active targeting; pH-response; Magnetic targeting therapy; Gambogic acid

摘要：Hydrophilic mesoporous organosilica nanoparticles (HMNPs) were synthesized by introducing Fe3O4 on the basis of mesoporous organosilicon nanoparticle hollow spheres as a drug carrier. N-and S-doped gra-phene quantum dots (NS-GQDs) and polyethylenimine (PEI) were grafted onto the surface of HMNPs. Finally, two types of composite mesoporous particles, HMNPs-NS-GQDs-PEI-HA and HMNPs-NS-GQDs-PEI-FA which can enter VX2 cells for fluorescence confocal imaging, were further modified by targeting ligand hyaluronic acid (HA) and folic acid (FA). The heteroatoms of NS-GQDs have intelligent functional effects, which can not only improve the photoluminescence performance of GQDs, but also generate con-jugated quantum dots with GA, so as to synergistically improve the drug effectiveness. Under illumina-tion by near-infrared (NIR) radiation, gambogic acid (GA)-loaded HMNPs was promoted to the sustained release of gambogic acid. The loading and sustained release of the anticancer drug GA on the compound mesoporous particles were studied. The cytotoxicity and antitumor properties of the compound meso-porous particles were investigated by both in vitro cell experiments and in vivo experiments in mice. The results showed that HMNPs-NS-GQDs-PEI-HA and HMNPs-NS-GQDs-PEI-FA have desired fluores-cence and magnetic properties for cell fluorescence imaging and magnetic targeting of cancer cells. Both of composite mesoporous particles have desired loading capacity on GA and pH-responsive drug release behavior as well as low cytotoxicity and good biocompatibility. The cell survival rate of HMNPs-NS-GQDs-PEI-HA and HMNPs-NS-GQDs-PEI-FA loaded with GA was only 7.69% and 8.71%, respectively, after 24 h, which can effectively induce the apoptosis of VX2 cells. Tumor experiments in mice demonstrated that HMNPs-NS-GQDs-PEI-HA inhibits tumor growth and exhibits magnetic targeting function. (C) 2022 Elsevier B.V. All rights reserved.