文献类型：期刊文献

中文题名：Reductive Metabolism of Nitroaromatic Compounds by Various Liver Microsomes

英文题名：Reductive Metabolism of Nitroaromatic Compounds by Various Liver Microsomes

作者：Wang Xing-yong[1,2];Cui Jing-nan[1];Ren Wei-min[1];Zhao Guo-quan[2];Li Feng[1];Qian Xu-hong[3]

机构：[1]Dalian Univ Technol, State Key Lab Fine Chem, Dalian 116012, Peoples R China;[2]China Univ Min & Technol, Sch Chem Engn & Technol, Xuzhou 221008, Peoples R China;[3]E China Univ Sci & Technol, Shanghai Key Lab Chem Biol, Shanghai 200237, Peoples R China

年份：2010

卷号：26

期号：6

起止页码：981

中文期刊名：Chemical Research in Chinese Universities

外文期刊名：CHEMICAL RESEARCH IN CHINESE UNIVERSITIES

收录：CSTPCD;;Scopus;WOS:【SCI-EXPANDED(收录号:WOS:000285276600025)】；CSCD:【CSCD2011_2012】；

基金：Supported by the National Basic Research Program of China(No.2009CB724706) and the National Natural Science Foundation of China(No.20876025).

语种：英文

中文关键词：Liver microsome; Reduction; Nitroaromatic compound; Aromatic hydroxylamine

外文关键词：Liver microsome; Reduction; Nitroaromatic compound; Aromatic hydroxylamine

摘要：Nitroaromatic compounds were reductively metabolized to the corresponding amine compounds via the intermediate hydroxylamines by liver microsomes from pig,rat,chook,cattle,sheep,paralichthys olivaceus and cyprinoid in varied reactivity.Similar with baker＇s yeast,the pig,rat and sheep liver microsomes exhibited high reactivity toward 4-nitro-1,2-dicyanbenzen（1a）,while the cyprinoid liver microsomes were inefficient.Contrasted to compound 1a,monocyannitrobenzene（2a） was difficult to reduce by pig liver microsomes.In opposition to grape cells,pig liver microsomes exhibited activities toward some aromatic hydroxylamine compounds.
Nitroaromatic compounds were reductively metabolized to the corresponding amine compounds via the intermediate hydroxylamines by liver microsomes from pig, rat, chook, cattle, sheep, paralichthys olivaceus and cyprinoid in varied reactivity. Similar with baker's yeast, the pig, rat and sheep liver microsomes exhibited high reactivity toward 4-nitro-1,2-dicyanbenzen(1a), while the cyprinoid liver microsomes were inefficient. Contrasted to compound la, monocyannitrobenzene(2a) was difficult to reduce by pig liver microsomes. In opposition to grape cells, pig liver microsomes exhibited activities toward some aromatic hydroxylamine compounds.