文献类型：期刊文献

英文题名：Tandem C-C/C-N Formation via Palladium-Catalyzed C-H Activation/Styrenation and Sequential Annulation of O-Methylketoxime with Styrenes

作者：Fu, Xiaopan[1];Yang, Jinyue[1];Deng, Kezuan[1];Shao, Lingyan[1];Xia, Chengcai[2];Ji, Yafei[1]

机构：[1]East China Univ Sci & Technol, Sch Pharm, 130 Meilong Rd, Shanghai 200237, Peoples R China;[2]Shandong First Med Univ & Shandong Acad Med Sci, Pharm Coll, 619 Changcheng Rd, Tai An 271016, Shandong, Peoples R China

年份：2019

卷号：21

期号：10

起止页码：3505

外文期刊名：ORGANIC LETTERS

收录：;WOS:【SCI-EXPANDED(收录号:WOS:000468696100008)，CCR-EXPANDED(收录号:WOS:000468696100008)】；

基金：We gratefully thank the National Natural Science Foundation of China (Project Nos. 21676088 and 21476074) for financial support.

语种：英文

摘要：A novel route for tandem C-C/C-N formation via palladium-catalyzed C-H activation/styrenation and annulation of O-methylketoxime with styrenes to synthesize benzothienopyridines and benzofuropyridines has been developed. Furthermore, the intermolecular alkenylation of the ketoxime with acrylates produces 3-alkenyl O-methylketoximes in good to excellent yields. The method features mild reaction conditions and good functional group tolerance, providing a direct approach for the preparation of fused heterocycles.