文献类型：期刊文献

英文题名：Redox-responsive supramolecular amphiphiles constructed via host-guest interactions for photodynamic therapy

作者：Liu, Feng[1];Ma, Yufei[1];Xu, Lei[1];Liu, Lichao[1];Zhang, Weian[1]

机构：[1]E China Univ Sci & Technol, Shanghai Key Lab Funct Mat Chem, Shanghai 200237, Peoples R China

年份：2015

卷号：3

期号：8

起止页码：1218

外文期刊名：BIOMATERIALS SCIENCE

收录：;EI(收录号：20152901048444);WOS:【SCI-EXPANDED(收录号:WOS:000357937400005)】；

基金：This work was financially supported by the National Natural Science Foundation of China (no. 51173044), Research Innovation Program of SMEC (no. 14ZZ065) and Shanghai Pujiang Program under 14PJ1402600. W. Z. also acknowledges the support from the Fundamental Research Funds for the Central Universities.

语种：英文

外文关键词：Porphyrins - Photodynamic therapy - Aggregates - Amphiphiles - High resolution transmission electron microscopy - Toxicity - Self assembly - Sulfur compounds - Dynamic light scattering - Micelles - Photosensitizers - Supramolecular chemistry

摘要：A supramolecular photosensitizer delivery system has been established through the self-assembly of supramolecular amphiphiles constructed by the host-guest interaction between poly(ethylene glycol)-beta-cyclodextrin (PEG-beta-CD) and adamantane-terminated porphyrin derivatives bearing a disulfide bond (TPPC6-SS-Ada). TPPC6-SS-Ada/PEG-beta-CD supramolecular amphiphiles can self-assemble into spherical micelles in water, and the assembled morphology was respectively characterized by transmission electron microscopy (TEM) and dynamic light scattering (DLS). Intracellular uptake and localization of supramolecular photosensitizers were further investigated by flow cytometry and confocal laser scanning microscopy (CLSM), and the result indicated that TPPC6-SS-Ada/PEG-beta-CD micelles could be effectively up-taken by MCF-7 cells. Furthermore, the phototoxicity evaluated by an MTT assay showed that TPPC6-SS-Ada/PEG-beta-CD micelles have very low dark toxicity but greater photo-toxicity compared to free porphyrin. Thus, TPPC6-SS-Ada/PEG-beta-CD micelles would provide the potential application for photosensitizer delivery.