文献类型：期刊文献

英文题名：Subtyping Cryptosporidium ubiquitum, a Zoonotic Pathogen Emerging in Humans

作者：Li, Na[1,2];Xiao, Lihua[2];Alderisio, Keri[3];Elwin, Kristin[4];Cebelinski, Elizabeth[5];Chalmers, Rachel[4];Santin, Monica[6];Fayer, Ronald[6];Kvac, Martin[7];Ryan, Una[8];Sak, Bohumil[7];Stanko, Michal[9];Guo, Yaqiong[1,2];Wang, Lin[1];Zhang, Longxian[10];Cai, Jinzhong[11];Roellig, Dawn[2];Feng, Yaoyu[1]

机构：[1]E China Univ Sci & Technol, Shanghai 200237, Peoples R China;[2]Ctr Dis Control & Prevent, Atlanta, GA USA;[3]New York City Dept Environm Protect, Flushing, NY USA;[4]UK Cryptosporidium Reference Unit, Swansea, W Glam, Wales;[5]Minnesota Dept Hlth, St Paul, MN USA;[6]USDA, Beltsville, MD 20705 USA;[7]Acad Sci Czech Republic, Ceske Budejovice, Czech Republic;[8]Murdoch Univ, Perth, WA, Australia;[9]Slovak Acad Sci, Kosice, Slovakia;[10]Henan Agr Univ, Zhengzhou, Peoples R China;[11]Qinghai Acad Vet Med & Anim Sci, Xining, Peoples R China

年份：2014

卷号：20

期号：2

起止页码：217

外文期刊名：EMERGING INFECTIOUS DISEASES

收录：;WOS:【SCI-EXPANDED(收录号:WOS:000330553800006)】；

基金：This study was supported in part by the National Natural Science Foundation of China (nos. 31229005, 31110103901, and 31302078); Open Funding Project of the State Key Laboratory of Veterinary Etiological Biology, Lanzhou, China; Fundamental Research Funds for the Central Universities, China; and the Ministry of Education, Youth and Sports of the Czech Republic (no. LH11061).

语种：英文

摘要：Cryptosporidium ubiquitum is an emerging zoonotic pathogen. In the past, it was not possible to identify an association between cases of human and animal infection. We conducted a genomic survey of the species, developed a subtyping tool targeting the 60-kDa glycoprotein (gp60) gene, and identified 6 subtype families (XIIa-XIIf) of C. ubiquitum. Host adaptation was apparent at the gp60 locus; subtype XIIa was found in ruminants worldwide, subtype families XIIb-XIId were found in rodents in the United States, and XIIe and XIIf were found in rodents in the Slovak Republic. Humans in the United States were infected with isolates of subtypes XIIb-XIId, whereas those in other areas were infected primarily with subtype XIIa isolates. In addition, subtype families XIIb and XIId were detected in drinking source water in the United States. Contact with C. ubiquitum-infected sheep and drinking water contaminated by infected wildlife could be sources of human infections.