文献类型：期刊文献

英文题名：Novel fluorescent markers for hypoxic cells of naphthalimides with two heterocyclic side chains for bioreductive binding

作者：Liu, Y; Xu, YF; Qian, XH; Liu, JW; Shen, LY; Li, JH; Zhang, YX

机构：[1]E China Univ Sci & Technol, Sch Pharm, Shanghai 200237, Peoples R China;[2]Shanghai Key Lab Chem Biol, Shanghai 200237, Peoples R China;[3]E China Univ Sci & Technol, State Key Lab Bioreactor Engn, Shanghai 200237, Peoples R China

年份：2006

卷号：14

期号：9

起止页码：2935

外文期刊名：BIOORGANIC & MEDICINAL CHEMISTRY

收录：;WOS:【SCI-EXPANDED(收录号:WOS:000236591200006)】；

语种：英文

外文关键词：fluorescent markets; hypoxic cells; naphthalimides; bioreductive binding; 2-nitroimidazole

摘要：Novel naphthalimides with two heterocyclic side chains of 2-nitroimidazole for bioreductive binding were designed, synthesized, and used as fluorescent markers for hypoxic cells. Their evaluation for imaging tumor hypoxia was carried Out in V79 cells, CHO cells, and 95D cells in vitro by using fluorescence scan ascent. A(2) and A(4) showed a very large differential fluorescence between hypoxic and oxic cells (V79 cells) in vitro and are promising candidate markers for hypoxic cells. (c) 2005 Elsevier Ltd. All rights reserved.