文献类型：期刊文献

英文题名：Enantioselective organocatalytic phospha-Michael reaction of α,β-unsaturated ketones

作者：Wen, Shigang[1];Li, Pengfei[1];Wu, Haibo[1];Yu, Feng[1];Liang, Xinmiao[1];Ye, Jinxing[1]

机构：[1]E China Univ Sci & Technol, Engn Res Ctr Pharmaceut Proc Chem, Minist Educ, Sch Pharm, Shanghai 200237, Peoples R China

年份：2010

卷号：46

期号：26

起止页码：4806

外文期刊名：CHEMICAL COMMUNICATIONS

收录：;WOS:【SCI-EXPANDED(收录号:WOS:000279045800045)，CCR-EXPANDED(收录号:WOS:000279045800045)】；

基金：We are grateful for the financial support from the National Natural Science Foundation of China (20902018), the Shanghai Pujiang Program (08PJ1403300), the Fundamental Research Funds for the Central Universities and 111 Project (B07023).

语种：英文

摘要：Enantioselective organocatalytic phospha-Michael reaction of alpha,beta-unsaturated ketones and diaryl phosphine oxides has been developed for the first time employing multifunctional organocatalysts. Optically active products bearing quaternary chiral carbon stereocenters were obtained in high yields with good to excellent enantioselectivities (up to 98% ee).