文献类型：期刊文献

英文题名：Highly Efficient and Stereoselective Construction of Bispirooxindole Derivatives via a Three-Component 1,3-Dipolar Cycloaddition Reaction

作者：Xu, Qin[1,2];Wang, De[1,2];Wei, Yin[3];Shi, Min[1,2,3]

机构：[1]E China Univ Sci & Technol, Sch Chem & Mol Engn, Key Lab Adv Mat, Shanghai 200237, Peoples R China;[2]E China Univ Sci & Technol, Sch Chem & Mol Engn, Inst Fine Chem, Shanghai 200237, Peoples R China;[3]Chinese Acad Sci, Shanghai Inst Organ Chem, State Key Lab Organometall Chem, Shanghai 200032, Peoples R China

年份：2014

卷号：3

期号：3

起止页码：93

外文期刊名：CHEMISTRYOPEN

收录：;EI(收录号：20231113727405);WOS:【SCI-EXPANDED(收录号:WOS:000337795900002)】；

基金：We are grateful for financial support from Shanghai Municipal Committee of Science and Technology, China (11JC1402600), the National Basic Research Program of China ((973)-2010CB833302), and the National Natural Science Foundation of China (20472096, 21372241, 21361140350, 20672127, 21102166, 21121062, 21302203 and 20732008).

语种：英文

外文关键词：azomethine ylides; bispirooxindoles; cycloaddition; stereochemistry; substituted olefins

摘要：A highly regio- and stereoselective synthesis of bispirooxindoles by 1,3-dipolar cycloaddition of in situ generated azomethine ylides from isatin and proline to different electron-deficient alkenes has been developed. The synthesis affords the desired bispiro scaffold compounds in excellent yields with high regioselectivity under mild conditions. The stereochemistry was determined by single-crystal X-ray analysis.