文献类型：期刊文献

英文题名：Ultrasmall Superparamagnetic Iron Oxide Nanoparticles for Magnetic Resonance Imaging Contrast Agent

作者：Zhao, Xueling[1,2];Zhao, Hongli[3];Chen, Zongyan[1,2];Lan, Minbo[3,4]

机构：[1]E China Univ Sci & Technol, Shanghai Key Lab Funct Mat Chem, Shanghai 200237, Peoples R China;[2]E China Univ Sci & Technol, Res Ctr Anal & Test, Shanghai 200237, Peoples R China;[3]E China Univ Sci & Technol, Inst Appl Chem, Shanghai 200237, Peoples R China;[4]E China Univ Sci & Technol, State Key Lab Bioreactor Engn, Shanghai 200237, Peoples R China

年份：2014

卷号：14

期号：1

起止页码：210

外文期刊名：JOURNAL OF NANOSCIENCE AND NANOTECHNOLOGY

收录：;EI(收录号：20140817341022);WOS:【SCI-EXPANDED(收录号:WOS:000331803900012)】；

基金：This research was financially supported by the National Natural Science Foundation of China (NSFC, contract No. 21074033) and the Science and Technology Commission of Shanghai Municipality (STCSM, contract Nos. 12 nm0501100 and 13ZR1412000).

语种：英文

外文关键词：Ultrasmall Superparamagnetic Iron Oxides (USPIOs); Magnetic Resonance Imaging (MRI); Contrast Agent; Reticuloendothelial System (RES); Blood Brain Barrier (BBB)

摘要：Nanotechnology has given scientists new tools for the development of advanced materials for the detection and diagnosis of various types of diseases. In particular, ultrasmall superparamagnetic iron oxides (USPIOs) have been investigated in many biological applications, both in vitro and in vivo. Due to their small size (diameter <20 nm), these particles are not immediately removed from the circulation by the reticuloendothelial system (RES), have a longer blood half-life, a wider biodistribution and allow potential targeting with appropriate bioconjugates to specific tissues both normal and tumorous. This review will mainly discuss the synthesis of USPIOs and their applications as MRI contrast agent for disease detection.