文献类型：期刊文献

英文题名：Lactiplantibacillus plantarum X7022 Plays Roles on Aging Mice with Memory Impairment Induced by D-Galactose Through Restoring Neuronal Damage, Relieving Inflammation and Oxidative Stress

作者：Yin, Deyi[1];Zhao, Li[1];Deng, Sijing[1];Xie, Yaqi[1];Ro, Kum-Song[1,2];Yang, Zeyong[3];Du, Lei[1];Xie, Jingli[1,4];Wei, Dongzhi[1,4]

机构：[1]East China Univ Sci & Technol, Sch Biotechnol, Dept Food Sci & Technol, State Key Lab Bioreactor Engn, 130 Meilong Rd, Shanghai 200237, Peoples R China;[2]Kim Hyong Jik Univ Educ, Fac Life Sci, Dept Biotechnol, Pyongyang 999093, North Korea;[3]Shanghai Jiao Tong Univ, Shanghai Municipal Key Clin Specialty, Shanghai Key Lab Embryo Original Dis,Sch Med, Int Peace Matern & Child Hlth Hosp,Dept Anesthesio, Shanghai 200030, Peoples R China;[4]Shanghai Collaborat Innovat Ctr Biomfg SCICB, Shanghai 200237, Peoples R China

年份：2025

卷号：17

期号：1

起止页码：1

外文期刊名：PROBIOTICS AND ANTIMICROBIAL PROTEINS

收录：;WOS:【SCI-EXPANDED(收录号:WOS:001137190600001)】；

基金：No Statement Available

语种：英文

外文关键词：Probiotics; Aging; Oxidative stress; Anti-inflammation; Gut microbiota

摘要：In this study, Lactiplantibacillus plantarum X7022 was applied to ameliorate memory impairment of aging mice induced by D-galactose. The strain showed specific choloylglycine hydrolysis ability based on in vitro investigation. Morris water maze test showed L. plantarum X7022 administration improved learning ability and spatial memory of aging mice. The gavage of L. plantarum X7022 displayed a promising ability of relieving cerebral oxidative stress and hippocampal inflammatory condition according to the increased GSH level and SOD activity and decreased MDA level, as well as decreased TNF-alpha, IL-1 beta, and IL-6 levels. The intervention with the strain could protect neuron by regulating cell apoptosis and AChE overexpression and inhibiting amyloid-beta deposition, as well as affect neuron functions by regulating CREB-BDNF signaling pathways and iNOS expression. Besides, the strain could improve fecal SCFA contents and increase the abundance of anti-inflammatory and antioxidant-related genera such as Lactobacillus, Akkermansia, and Adlercreutzia. These results suggest that L. plantarum X7022 could be a prospective therapeutic alternative for the improvement of memory impairment among the elderly.