文献类型：期刊文献

英文题名：Enantioselective resolution of 4-chloromandelic acid by liquid-liquid extraction using 2-chloro-N-carbobenzyloxy-L-amino acid

作者：Lu, Ruichen[1];He, Quan[2];Feng, Cai[1];Peng, Yangfeng[1]

机构：[1]East China Univ Sci & Technol, Sch Chem Engn, 130 Meilong Rd, Shanghai 200237, Peoples R China;[2]Dalhousie Univ, Dept Engn, Fac Agr, Truro, NS, Canada

年份：2017

卷号：29

期号：11

起止页码：708

外文期刊名：CHIRALITY

收录：;WOS:【SCI-EXPANDED(收录号:WOS:000412662100006)】；

语种：英文

外文关键词：2-chloro-N-carbobenzyloxy-L-amino acid; 4-chloromandelic acid; chiral separation; liquid-liquid extraction; N-(2-chlorobenzyloxy)-succinimide; valine

摘要：A liquid-liquid extraction resolution of 4-chloro-mandelic acid (4-ClMA) was studied by using 2-chloro-N-carbobenzyloxy-L-amino acid (2-Cl-Z-AA) as a chiral extractant. Important factors affecting the extraction efficiency were investigated, including the type of chiral extractant, pH value of aqueous phase, initial concentration of chiral extractant in organic phase, initial concentration of 4-ClMA in aqueous phase, and resolution temperature. It was observed that the concentration of (R)-4-ClMA was much higher than that of (S)-4-ClMA in organic phase due to a higher stability of the complex formed between (R)-4-ClMA and 2-Cl-Z-AA. A separation factor () of 3.05 was obtained at 0.02 mol/L 2-Cl-Z-Valine dissolved in dichloromethane, pH of 2.0, concentration of 4-ClMA of 0.11 mmol/Land T of 296.7K.