文献类型：期刊文献

英文题名：Concise synthesis of (+)-subersic acid from (-)-Sclareol

作者：Wang, Peiqiang[1];Li, Jue[1];Yu, Chen-Lin[1];Xiao, Xiong[1];Wu, Pei-Ying[2];Zeng, Bu-Bing[1,3]

机构：[1]E China Univ Sci & Technol, Shanghai Key Lab New Drug Design, Shanghai 200237, Peoples R China;[2]Shanghai Univ Tradit Chinese Med, Shanghai 201203, Peoples R China;[3]Chinese Acad Sci, Shanghai Inst Organ Chem, Key Lab Synthet Chem Nat Subst, Shanghai 200032, Peoples R China

年份：2015

卷号：71

期号：28

起止页码：4647

外文期刊名：TETRAHEDRON

收录：;WOS:【SCI-EXPANDED(收录号:WOS:000356557000010)，CCR-EXPANDED(收录号:WOS:000356557000010)】；

基金：We thank the National High Technology Research and Development Program of China (2007AA02Z301) for the generous financial support. We are also grateful for the financial support from the Fundamental Research Funds for the Central University (WY111307).

语种：英文

外文关键词：(+)-Subersic acid; [3,3]-Claisen rearrangement; Mitsunobu reaction; (-)-Sclareol

摘要：A short and efficient synthesis of (+)-subersic acid in 6 steps with an overall yield of 8.6% from (-)-Sclareol was presented using Mitsunobu reaction and Claisen rearrangement as critical steps. This elegant protocol gave a convenient access to gram scales of (+)-subersic acid, which could be a precursor for its structural analogues and for further bioactivity researches. (C) 2015 Elsevier Ltd. All rights reserved.