文献类型：期刊文献

英文题名：Influences of tantalum pentoxide and surface coarsening on surface roughness, hydrophilicity, surface energy, protein adsorption and cell responses to PEEK based biocomposite

作者：Mei, Shiqi[1];Yang, Lili[2];Pan, Yongkang[1];Wang, Deqiang[1];Wang, Xuehong[1];Tang, Tingting[3];Wei, Jie[1]

机构：[1]East China Univ Sci & Technol, Key Lab Ultrafine Mat, Minist Educ, Shanghai 200237, Peoples R China;[2]Second Mil Med Univ, Changzheng Hosp, Dept Orthopaed Surg, Shanghai 200003, Peoples R China;[3]Shanghai Jiao Tong Univ, Sch Med, Shanghai Peoples Hosp 9, Dept Orthopaed Surg,Shanghai Key Lab Orthopaed Im, Shanghai 200011, Peoples R China

年份：2019

卷号：174

起止页码：207

外文期刊名：COLLOIDS AND SURFACES B-BIOINTERFACES

收录：;EI(收录号：20184706116413);WOS:【SCI-EXPANDED(收录号:WOS:000459840800025)】；

基金：This work was supported by the National Natural Science Foundation of China (grant numbers 81572194, 81771990), National Key R&D Program (2016YFC1102100) and the Key Medical Program of Science and Technology Development of Shanghai (grant numbers 15441902500, 17441900600 and 17441902000).

语种：英文

外文关键词：Polyetheretherketone; Tantalum pentoxide; Biocomposites; Surface coarsening; Cytocompatibility

摘要：Polyetheretherketone (PEEK) biomaterial has become increasingly popular in orthopedic applications due to its favorable biocompatibility, biostability, mechanical strength and elastic modulus similar to natural bones. In this research, in order to improve the biological performances of PEEK, tantalum pentoxide (Ta2O5) was incorporated into PEEK to fabricate PEEK/Ta2O5 composites (PTC) using a method of cold press-sintering, and surface coarsening of PTC was prepared by sand blasting. The results showed that the Ta2O5 particles were uniformly disperse into PEEK, and thermal and mechanical properties of PTC were enhanced with the increase of Ta2O5 content. In addition, incorporating Ta2O5 into PEEK and surface coarsening could improve surface roughness, hydrophilicity, surface energy and protein absorption of PTC. Furthermore, the adhesion and proliferation as well as osteogenic differentiation of BMSCs on PTC were significantly promoted and regulated by Ta2O5 content and surface coarsening. The results indicated that surface coarsening of PTC (PTCS) with high surface roughness, hydrophilicity and surface energy could induce positive cellular responses, showing good cytocompatibility. PTCS might have a great potential as implants for bone repair.