文献类型：期刊文献

英文题名：Enhancing Photochemical Internalization of DOX through a Porphyrin-based Amphiphilic Block Copolymer

作者：Tian, Jia[2];Xu, Lei[2];Xue, Yudong[2];Jiang, Xiaoze[1];Zhang, Weian[1,2]

机构：[1]Donghua Univ, State Key Lab Modificat Chem Fibers & Polymer Mat, Shanghai 201620, Peoples R China;[2]East China Univ Sci & Technol, Shanghai Key Lab Funct Mat Chem, Shanghai 200237, Peoples R China

年份：2017

卷号：18

期号：12

起止页码：3992

外文期刊名：BIOMACROMOLECULES

收录：;EI(收录号：20175104557853);WOS:【SCI-EXPANDED(收录号:WOS:000418109200012)】；

基金：This work was financially supported by the National Natural Science Foundation of China (no. 21574039) and the State Key Laboratory for Modification of Chemical Fibers and Polymer Materials, Donghua University.

语种：英文

外文关键词：Controlled drug delivery - Targeted drug delivery - pH sensors - Photosensitizers - Chemotherapy - Block copolymers - Efficiency - Micelles

摘要：Drug resistance is a primary obstacle that seriously reduces the therapy efficiency of most chemotherapeutic agents. To address this issue, the photochemical internalization (PCI) was employed to help the anticancer drug escape from lysosome and improve their translocation to the nucleus. A pH-sensitive porphyrin-based amphiphilic block copolymer (PEG(113)-b-PCL54-a-porphyrin) was synthesized, which was acted not only as a carrier for the delivery of DOX but also as a photosensitizer for PCI. PEG(113)-b-PCL54-a-porphyrin as a drug carrier exhibited a higher drug loading capacity, entrapment efficiency, and DOX release content. The PCI effect of PEG(113)-b-PCL54-a-porphyrin was studied by confocal laser scanning microscopy, and the results showed that most of DOX could be translocated into the nucleus for DOX-loaded PEG(113)-b-PCL54-a-porphyrin micelles. Moreover, the IC50 of pH-sensitive DOX-loaded PEG(113)-b-PCL54-a-porphyrin micelles was much lower than that of its counterpart without pH-responsiveness, DOX-loaded PEG(113)-b-PCL54-porphyrin micelles. Therefore, this drug delivery system based on pH-sensitive porphyrin-containing block copolymer would act as a potential vehicle for overcoming drug resistance in chemotherapy.