文献类型：期刊文献

中文题名：Perpyrrospirone A, an unprecedented hirsutellone peroxide from the marine-derived Penicillium citrinum

作者：Yi Ding[1];Yu Jiang[1];Sunjie Xu[1];Xiujuan Xin[1];Faliang An[1]

机构：[1]State Key Laboratory of Bioreactor Engineering,East China University of Science and Technology,Shanghai 200237,China

年份：2023

卷号：34

期号：2

起止页码：463

中文期刊名：Chinese Chemical Letters

外文期刊名：中国化学快报（英文版）

收录：CSTPCD;;Scopus;CSCD:【CSCD2023_2024】；PubMed;

基金：funded by the National Natural Science Foundation of China (Nos. 41876189, 81703388);the National Key R&D Program of China (Nos. 2018YFC1706206, 2019YFC0312504);supported by the Open Research Fund Program of State Key Laboratory of Bioreactor Engineering and Institute of Regulatory Science。

语种：英文

中文关键词：Penicillium citrinum;Hirsutellone;Peroxide;X-ray;Cytotoxicity

摘要：Perpyrrospirone A(1) characterized an unprecedented 6/5/6/8/5/13/6 oxahexacyclic scaffold with a unique peroxide-bridged 8,9-dioxa-2-azaspiro[4.7]dodecane core from marine-derived Penicillium citrinum. Compounds 2 and 3 possessed rare oxatetracyclic(6/5/6/5) skeleton fused with a 13-menberedring macrocyclic moiety. Their structure and absolute configurations were determined by comprehensive spectroscopic analyses, ECD data coupled with TD-DFT calculations and X-ray diffraction experiments. In addition, 7 showed cytotoxicity and induced apoptosis of Hela cells in a dose-dependent manner after a48 h treatment.