文献类型：期刊文献

英文题名：Cyclic D/L-peptides based nanoparticles regulates dendritic cell maturation and enhances anti-tumor immune response

作者：Hu, Wei[1];Xu, Jiaxi[1];Lv, Mingchen[1];Sun, Min[2];Fan, Zhen[1];Du, Jianzhong[1,2]

机构：[1]Tongji Univ, Sch Mat Sci & Engn, Dept Polymer Mat, 4800 Caoan Rd, Shanghai 201804, Peoples R China;[2]East China Univ Sci & Technol, Sch Mat Sci & Engn, Shanghai 200237, Peoples R China

年份：2026

卷号：66

外文期刊名：NANO TODAY

收录：;EI(收录号：20254719543324);WOS:【SCI-EXPANDED(收录号:WOS:001623057900001)】；

基金：This research was supported by National Natural Science Foundation of China (52222306, 22335005, 22475154 and 22305177) , Interna-tional scientific collaboration fund of Science and Technology Com-mission of Shanghai Municipality (23520710900) , Innovation Program of Shanghai Municipal Education Commission (2023ZKZD28) , Shanghai Rising-Star Program (Sailing, 23YF1433000) , the Fundamental Research Funds for the Central Universities.

语种：英文

外文关键词：Peptide; Self-assembling; Immunotherapy; Chirality

摘要：Immunotherapy offers enduring cancer treatment by activating the immune system to eliminate cancer cells, but faces challenges like tumor immune evasion and low immunogenicity. Chirality, crucial in biological interactions, remains underexplored for immune modulation. Inspired by the metal-binding domain of manganese superoxide dismutase, we develop a cyclic D/L peptide for chirality-driven immune activation. The cyclic L-TyrD-His-L-Asp-D-His (YhDh) peptide coordinates with Mn2+ to self-assemble into nanoparticles, cloak with tumor cell membranes for homologous targeting. Compared to all-L or all-D peptides, YhDh nanoparticles promote costimulatory molecule expression on dendritic cells (DCs). Upon intravenous administration, they are oxidized at melanoma sites with tyrosinase overexpression, enabling photothermal-induced immunogenic cell death (ICD). Chiral peptides synergize with Mn2+-mediated cGAS-STING activation and ICD, enhancing DC maturation and T cell infiltration (4.36- and 2.88-fold), suppressing tumor metastasis while establishing immune memory. Such chiral cyclic peptides offer a novel strategy for immune activation by regulating peptide chirality.