文献类型：期刊文献

英文题名：Cinchona Alkaloid Squaramide/AgOAc Cooperatively Catalyzed Diastereo- and Enantioselective Mannich/Cyclization Cascade Reaction of Isocyanoacetates and Cyclic Trifluoromethyl Ketimines

作者：Zhao, Mei-Xin[1,2,3];Bi, Hong-Lei[1,2];Jiang, Rong-Hui[1,2];Xu, Xu-Wei[1,2];Shi, Min[1,2,4]

机构：[1]E China Univ Sci & Technol, Key Lab Adv Mat, Shanghai 200237, Peoples R China;[2]E China Univ Sci & Technol, Inst Fine Chem, Shanghai 200237, Peoples R China;[3]Chinese Acad Sci, Inst Chem, CAS Key Lab Mol Recognit & Funct, Beijing 100190, Peoples R China;[4]Chinese Acad Sci, Shanghai Inst Organ Chem, State Key Lab Organometall Chem, Shanghai 200032, Peoples R China

年份：2014

卷号：16

期号：17

起止页码：4566

外文期刊名：ORGANIC LETTERS

收录：;WOS:【SCI-EXPANDED(收录号:WOS:000341344600056)，CCR-EXPANDED(收录号:WOS:000341344600056)】；

基金：We are grateful for financial support from the National Natural Science Foundation of China (20772030, 21072056, 21272067) and the Fundamental Research Funds for the Central Universities.

语种：英文

摘要：An efficient diastereo- and enantioselective Mannich-type/cyclization cascade reaction of alpha-substituted isocyanoacetates and cyclic trifluoromethyl ketimines cooperatively catalyzed by cinchona alkaloid-derived multi-hydrogen-bonding donor squaramide and AgOAc has been investigated, affording the optically active trifluoromethyl-substituted tetrahydroimidazo[1,5-c]-quinazoline derivatives in excellent yields (up to 99%) and good to excellent stereoselectivities (up to >15:1 dr, up to 9896 cc) under mild conditions.