文献类型：期刊文献

英文题名：Perpyrrospirone A, an unprece dente d hirsutellone peroxide from the marine-derived Penicillium citrinum

作者：Ding, Yi[1];Jiang, Yu[1];Xu, Sunjie[1];Xin, Xiujuan[1];An, Faliang[1]

机构：[1]East China Univ Sci & Technol, State Key Lab Bioreactor Engn, Shanghai 200237, Peoples R China

年份：2023

卷号：34

期号：2

外文期刊名：CHINESE CHEMICAL LETTERS

收录：;WOS:【SCI-EXPANDED(收录号:WOS:000910205500001)】；

基金：This work was funded by the National Natural Science Foundation of China (Nos. 41876189 , 81703388) , and the National Key R & D Program of China (Nos. 2018YFC1706206, 2019YFC0312504) . This work was also supported by the Open Research Fund Program of State Key Laboratory of Bioreactor Engineering and Institute of Regulatory Science.

语种：英文

外文关键词：Penicillium citrinum; Hirsutellone; Peroxide; X-ray; Cytotoxicity

摘要：Perpyrrospirone A ( 1 ) characterized an unprecedented 6/5/6/8/5/13/6 oxahexacyclic scaffold with a unique peroxide-bridged 8,9-dioxa-2-azaspiro[4.7]dodecane core from marine-derived Penicillium cit-rinum. Compounds 2 and 3 possessed rare oxatetracyclic (6/5/6/5) skeleton fused with a 13-menbered-ring macrocyclic moiety. Their structure and absolute configurations were determined by comprehensive spectroscopic analyses, ECD data coupled with TD-DFT calculations and X-ray diffraction experiments. In addition, 7 showed cytotoxicity and induced apoptosis of Hela cells in a dose-dependent manner after a 48 h treatment.(c) 2022 Published by Elsevier B.V. on behalf of Chinese Chemical Society and Institute of Materia Medica, Chinese Academy of Medical Sciences.