文献类型：期刊文献

英文题名：Ring-opening polymerization of N-carboxyanhydrides: An efficient approach toward peptides, peptoids, and functional materials

作者：Song, Pengyu[1];Lv, Jiachen[1];Yang, Chun[1];Gu, Qianxi[1];Liu, Shangning[1];Zhang, Yuanzu[1];Wang, Wenli[2];Zhu, Yunqing[1,4];Du, Jianzhong[2,3,4]

机构：[1]Tongji Univ, Sch Mat Sci & Engn, Dept Polymer Mat, 4800 Caoan Rd, Shanghai 201804, Peoples R China;[2]Tongji Univ, Shanghai Peoples Hosp 4, Translat Res Inst Brain & Brain Like Intelligence, Clin Res Ctr Anesthesiol & Perioperat Med, Shanghai 200434, Peoples R China;[3]Tongji Univ, Sch Mat Sci & Engn, Key Lab Adv Civil Engn Mat, Minist Educ, 4800 Caoan Rd, Shanghai 201804, Peoples R China;[4]East China Univ Sci & Technol, Sch Mat Sci & Engn, Shanghai 200237, Peoples R China

年份：2025

卷号：169

外文期刊名：PROGRESS IN POLYMER SCIENCE

收录：;EI(收录号：20253719128424);WOS:【SCI-EXPANDED(收录号:WOS:001569067300001)】；

基金：The authors acknowledge the financial support from National Natural Science Foundation of China (22335005 , 22401216 , and 22175131) , Tongcheng Youth Research and Development Fund (CPCIF-RA-0104) , Innovation Program of Shanghai Municipal Education Commission (2023ZKZD28) , and the Fundamental Research Funds for the Central Universities.

语种：英文

外文关键词：Ring-opening polymerization; Polypeptides; Self-assembly; Functional materials; N-carboxyanhydrides

摘要：Polypeptides, as one of the most remarkable biomacromolecules in nature, possess immense application potential due to their protein-mimetic architectures. Since the discovery of N-carboxyanhydride (NCA) monomers in the early 20th century, these cyclic derivatives have revolutionized polypeptide synthesis by overcoming the inherent challenges in amino acid polycondensation. NCA remains an active research frontier in polymer science and materials engineering. In this review we critically summarize recent advances in NCA-based polymerization strategies. We first highlight ring-opening polymerization approaches, followed by an in-depth discussion on copolymerization systems with emphasis on monomer compatibility. As molecular assembly serves as the critical bridge connecting polymer synthesis to functional applications, we subsequently analyze various self-assembly mechanisms of NCA-derived polypeptides, with a focus on elucidating the driving forces underlying different supramolecular architectures. Furthermore, we comprehensively overview the emerging functional applications of these polypeptide materials across biomedical and nanotechnology domains. We critically analyze persistent challenges while charting emergent research frontiers in this field. This review not only consolidates the recent progress in NCA polymerization but also provides mechanistic insights into molecular assembly and a roadmap for advancing functional polypeptide materials in next-generation applications. (c) 2025 Elsevier Ltd. All rights are reserved, including those for text and data mining, AI training, and similar technologies.