文献类型：期刊文献

英文题名：Decellularized extracellular matrix and mesenchymal stem cells promote recovery in traumatic brain injury by synergistically enhancing neurogenesis and attenuating neuroinflammation

作者：Zhang, Xuewei[1];Wang, Bixue[1];Hong, Hua[1];Wang, Ying[1];Liu, Jiashang[1];Liu, Changsheng[1];Chen, Xi[1]

机构：[1]East China Univ Sci & Technol, Frontiers Sci Ctr Materiobiol & Dynam Chem, Engn Res Ctr Biomat, Sch Mat Sci & Engn,Minist Educ,Key Lab Ultrafine M, Shanghai 200237, Peoples R China

年份：2023

卷号：138

起止页码：17

外文期刊名：JOURNAL OF MATERIALS SCIENCE & TECHNOLOGY

收录：;EI(收录号：20225013253942);WOS:【SCI-EXPANDED(收录号:WOS:000880674000002)】；

基金：This work was financially supported by the National Natural Science Foundation of China (Nos. 51621002 and 32101151) , and the Fundamental Research Funds for the Central Universities (No. JKD01221714) . We acknowledge Prof. X.D. Kong (Zhejiang Sci-Tech University) and Prof. Q.H. Li (Wenzhou Institute, University of Chi- nese Academy of Sciences) for helpful discussion. Any opinions, findings, conclusions, or recommendations expressed herein are those of the author (s) .

语种：英文

外文关键词：ECM; Stem cells; Brain injury; Neurogenesis; Neuroinflammation

摘要：Damaged neurons and harsh microenvironments contribute to the injury cascades following traumatic brain injury (TBI). Mesenchymal stem cell (MSC) therapy is considered a viable choice for brain in-jury treatment; however, its clinical use is hindered by limited engraftment, low survival ratio, and uncontrolled differentiation. Herein, the decellularized brain extracellular matrix (dBECM) was prepared through a new method as a delivery system for MSCs. dBECM-based hydrogel with favorable biochem-ical and biomechanical features provides a microenvironment for MSCs in nerve repair. The MSCs-encapsulated dBECM-based hydrogel is shown to improve neuron compensation and structural regen-eration, alleviate neuroinflammation, and promote M1-to-M2 polarization of microglia. Our results first demonstrate that the combination of dBECM and MSCs is a critical vehicle to promote TBI repair from neurogenesis and immunoregulation, showing promise for the physiological recovery of neurogenic dis-eases and injuries.(c) 2022 Published by Elsevier Ltd on behalf of The editorial office of Journal of Materials Science & Technology.