文献类型：期刊文献

英文题名：Development of magnesium calcium phosphate biocement for bone regeneration

作者：Jia, Junfeng[1,2];Zhou, Huanjun[1,2];Wei, Jie[1,2];Jiang, Xin[1,2];Hua, Hong[1,2];Chen, Fangping[1,2];Wei, Shicheng[3];Shin, Jung-Woog[4];Liu, Changsheng[1,2]

机构：[1]E China Univ Sci & Technol, Minist Educ, Key Lab Ultrafine Mat, Shanghai 200237, Peoples R China;[2]E China Univ Sci & Technol, Minist Educ, Engn Res Ctr Biomed Mat, Shanghai 200237, Peoples R China;[3]Peking Univ, Acad Adv Interdisciplinary Studies, Ctr Biomed Mat & Tissue Engn, Beijing 100871, Peoples R China;[4]Inje Univ, Dept Biomed Engn, Res Grp BK 21 1, Gimhae 621749, South Korea

年份：2010

卷号：7

期号：49

起止页码：1171

外文期刊名：JOURNAL OF THE ROYAL SOCIETY INTERFACE

收录：;EI(收录号：20103313163730);WOS:【SCI-EXPANDED(收录号:WOS:000279180600004)】；

基金：The authors appreciate financial support from the National Natural Science Funds of China (no. 30970720), Nano special programme of Science and Technology Development of Shanghai (no. 0852nm02700), Standard Special programme of Science and Technology Development of Shanghai (no. 08DZ0501600), Major Programme of National Natural Science Foundation of China (no. 50732002), Programme for Changjiang Scholars and Innovative Research Team in University, and Sponsored by Shanghai Pujiang Programme (2008).

语种：英文

外文关键词：magnesium phosphate; calcium phosphate; biocement; degradation; biocompatibility

摘要：Magnesium calcium phosphate biocement (MCPB) with rapid-setting characteristics was fabricated by using the mixed powders of magnesium oxide (MgO) and calcium dihydrogen phosphate (Ca(H(2)PO(4))(2)center dot H(2)O). The results revealed that the MCPB hardened after mixing the powders with water for about 7 min, and the compressive strength reached 43 MPa after setting for 1 h, indicating that the MCPB had a short setting time and high initial mechanical strength. After the acid-base reaction of MCPB containing MgO and Ca(H(2)PO(4))(2)center dot H(2)O in a molar ratio of 2 : 1, the final hydrated products were Mg(3)(PO(4))(2) and Ca(3)(PO(4))(2). The MCPB was degradable in Tris-HCl solution and the degradation ratio was obviously higher than calcium phosphate biocement (CPB) because of its fast dissolution. The attachment and proliferation of the MG(63) cells on the MCPB were significantly enhanced in comparison with CPB, and the alkaline phosphatase activity of MG(63) cells on the MCPB was significantly higher than on the CPB at 7 and 14 days. The MG(63) cells with normal phenotype spread well on the MCPB surfaces, and were attached in close proximity to the substrate, as seen by scanning electron microscopy (SEM). The results demonstrated that the MCPB had a good ability to support cell attachment, proliferation and differentiation, and exhibited good cytocompatibility.