文献类型：期刊文献

英文题名：Porphyrin-containing amphiphilic block copolymers for photodynamic therapy

作者：Xu, Lei[1];Liu, Lichao[1];Liu, Feng[1];Cai, Haibo[1];Zhang, Weian[1]

机构：[1]E China Univ Sci & Technol, Shanghai Key Lab Adv Polymer Mat, State Key Lab Bioreactor Engn, Shanghai 200237, Peoples R China

年份：2015

卷号：6

期号：15

起止页码：2945

外文期刊名：POLYMER CHEMISTRY

收录：;EI(收录号：20151500722389);WOS:【SCI-EXPANDED(收录号:WOS:000352089500016)】；

基金：This work was financially supported by the National Natural Science Foundation of China (no. 51173044), Research Innovation Program of SMEC (no. 14ZZ065), Shanghai Pujiang Program under 14PJ1402600, and the Open Funding Project of the State Key Laboratory of Bioreactor Engineering. W. Z. also acknowledges the support from the Fundamental Research Funds for the Central Universities.

语种：英文

外文关键词：Photosensitizers - Porphyrins - Monomers - Photodynamic therapy - Living polymerization - Micelles

摘要：Amphiphilic PNIPAM-b-PTPPC6MA block copolymers were first synthesized using porphyrin-containing monomers. The mono-hydroxylphenyl-triphenylporphyrin photosensitizer, TPP-OH, was modified into a porphyrin monomer, and it was further used to construct the amphiphilic PNIPAM-b-PTPPC6MA block copolymers using RAFT polymerization. PNIPAM-b-PTPPC6MA block copolymers can self-assemble into a plethora of morphologies ranging from spheres to vesicular aggregates and further to a single large vesicle. The PNIPAM-b-PTPPC6MA micelles exhibited a high singlet oxygen quantum yield. Moreover, confocal laser scanning microscopy (CLSM) and flow cytometry analysis confirmed that PNIPAM-b-PTPPC6MA micelles could effectively enhance the internalization rate in MCF-7 cells. According to the MTT assay, PNIPAM-b-PTPPC6MA micelles exhibited low dark toxicity and efficient PDT efficacy towards MCF-7 cells. Thus PNIPAM-b-PTPPC6MA block copolymers have the potential application for photodynamic therapy.