文献类型：期刊文献

中文题名：Towards efficient terpenoid biosynthesis: manipulating IPP and DMAPP supply

作者：Qin Wang[1];Shu Quan[2];Han Xiao[1]

机构：[1]State Key Laboratory of Microbial Metabolism,Joint International Research Laboratory of Metabolic & Developmental Sciences,and Laboratory of Molecular Biochemical Engineering,School of Life Sciences and Biotechnology,Shanghai Jiao Tong University,800 Dong-chuan Road,Shanghai,200240,China;[2]State Key Laboratory of Bioreactor Engineering,East China University of Science and Technology,Shanghai Collaborative Innovation Center for Biomanufacturing (SCICB),Shanghai,200237,China

年份：2019

卷号：6

期号：1

起止页码：547

中文期刊名：Bioresources and Bioprocessing

外文期刊名：生物资源与生物加工(英文)

基金：supported by the National Natural Science Foundation of China (No.31600071);Municipal Natural Science Foundation of Shanghai (Nos.17ZR1448900,18ZR1420300);Open Funding Project of the State Key Laboratory of Bioreactor Engineering.

语种：英文

中文关键词：Terpenoid;Mevalonate pathway;2-C-Methyl-d-erythritol 4-phosphate(MEP);Isopentenyl diphosphate(IPP);Dimethylallyl diphosphate(DMAPP);Biosynthesis

摘要：Terpenoids are a group of largest natural products with important biological functions,and their efficient biosynthesis is of particular importance to both academia and industry.As the building blocks for terpenoid biosynthesis,a suitable supply of isopentenyl diphosphate (IPP) and dimethylallyl diphosphate (DMAPP) is extremely crucial for efficient terpenoid biosynthesis.With this focus,we first introduce biosynthetic pathways of IPP and DMAPP,and then summarize the current strategies adopted for manipulating IPP and DMAPP supply.At last,how to further manage IPP and DMAPP supply to improve terpenoid biosynthesis is also proposed.