文献类型：期刊文献

英文题名：A pH/reduction dual-sensitive copolymer inserted in liposomal bilayer acts as a protective "umbrella"

作者：Wang, Yizhou[1,2];Lei, Bin[1,2];Xu, Jun[1,2];Sun, Minjia[1,2];Xu, Shouhong[1,2];Liu, Honglai[1,2]

机构：[1]East China Univ Sci & Technol, Shanghai Engn Res Ctr Hierarch Nanomat, Shanghai 200237, Peoples R China;[2]East China Univ Sci & Technol, Sch Chem & Mol Engn, Shanghai 200237, Peoples R China

年份：2020

卷号：602

外文期刊名：COLLOIDS AND SURFACES A-PHYSICOCHEMICAL AND ENGINEERING ASPECTS

收录：;EI(收录号：20202508847816);WOS:【SCI-EXPANDED(收录号:WOS:000562670800008)】；

基金：This work was supported by the National Natural Science Foundation of China (No. 21776071).

语种：英文

外文关键词：pH/reduction dual-sensitivity; Liposome; Controllable release; Precise delivery

摘要：Developing a targeted intelligent drug delivery system with excellent controllability of drug release remains an ongoing challenge in chemotherapy. A multistage responsive liposome was constructed by inserting a folate (FA) modified lipid and a pH/reduction dual-sensitive copolymer into the liposome bilayer. The properties of liposome were studied by fluorescence polarization, dynamic light scattering and in vitro drug release. Since the PDPA segment of the copolymer could embed in or escape from the liposomal bilayer depending on pH value, the membrane stability of the liposome was improved at pH 7.4 and decreased at pH 5.0. As a result, the drug leakage of the liposome was significantly suppressed at pH 7.4 but promoted at an acidic pH. Moreover, the liposome Lipo5-FA, which contained negatively charged FA groups protected by the longer PEG, was found to undergo membrane fusion with the positively charged Lipo( + ) to verify the longer PEG was cut by GSH. All results indicated that the smart copolymer acted as a switch on liposomal bilayer for drug release and also a protective "umbrella" for FA.