文献类型：期刊文献

英文题名：Chair-Shaped Indoline Donor Enabling Near-Infrared Imaging-Guided Type I Photodynamic Therapy

作者：Yi, Guofeng[1,2];Xu, Qiqi[1,2];Liu, Haodong[3];Ma, Chenggong[1,2];Wang, Ying[1,2,4];Zhao, Weijun[1,2,4];Wang, Chengyun[1,2]

机构：[1]East China Univ Sci & Technol, Inst Fine Chem, Key Lab Adv Mat, Shanghai 200237, Peoples R China;[2]East China Univ Sci & Technol, Feringa Nobel Prize Scientist Joint Res Ctr, Joint Int Res Lab Precis Chem & Mol Engn, Inst Fine Chem,Shanghai Key Lab Funct Mat Chem, Shanghai 200237, Peoples R China;[3]Nanjing Tech Univ, Inst Adv Mat IAM, Sch Flexible Elect Future Technol, State Key Lab Flexible Elect KLOFE, Nanjing 211816, Peoples R China;[4]East China Univ Sci & Technol, Ctr Photosensit Chem Engn, Shanghai 200237, Peoples R China

年份：2026

卷号：9

期号：7

起止页码：3529

外文期刊名：ACS APPLIED BIO MATERIALS

收录：EI(收录号：20261520455760);WOS:【ESCI(收录号:WOS:001771219400001)】；

基金：The authors are grateful to financial support from the Basic Science Center of National Natural Science Foundation (T2488302), National Natural Science Foundation of China (9235630033, 22105069, 22275085, 62305276, 92356301, 22338006, and 2250040112), China National Postdoctoral Program for Innovative Talents under Grant (BX20250111), Shanghai Natural Science Foundation (25ZR1402112), Innovation Program of Shanghai Municipal Education Commission (2023FGS01), Science and Technology Commission of Shanghai Municipality (24DX1400200), Natural Science Foundation of Jiangsu Province (BK20231225), and the China Postdoctoral Science Foundation (2024T170271 and 2025M771055).

语种：英文

外文关键词：aggregation-induced emission; type I photosensitizer; reactive oxygen species; photodynamic therapy; near-infrared imaging

摘要：Imaging-guided photodynamic therapy (PDT) represents a promising treatment modality owing to its high precision and minimal invasiveness. However, insufficient oxygen supply within solid tumors and aggregation-caused quenching (ACQ) of photosensitizers (PSs) limit the clinical application of imaging-guided PDT. Herein, we developed a type I reactive oxygen species (ROS) predominant photosensitizer (IDL-CPy) based on a unique chair-shaped ultra-strong electron donor indoline with aggregation-induced emission (AIE) characteristics, enabling imaging-guided type I PDT. The electron-rich indoline structure enhances intramolecular charge transfer, which narrows the singlet-triplet energy gap, thereby facilitating type I ROS generation. Theoretical and experimental analyses demonstrate that IDL-CPy exhibits an ideal intersystem crossing rate and triplet excited state lifetime for generating ROS, contributing to potent anticancer efficacy in vitro (IC50 = 0.34 mu M). This research represents the first indoline-based AIE photosensitizers and provides a promising candidate for imaging-guided type I PDT.