文献类型：期刊文献

英文题名：Asymmetric synthesis of (1S,6R,7S,9R)-7,9-bis(tert-butyldiphenylsilyloxy)-3-oxabicyclo[4,3,0]nonan-2-one

作者：Shi, XX; He, W; Wu, QQ; Yin, J; Ni, F; Jin, XZ

机构：[1]E China Univ Sci & Technol, Fac Chem & Pharmaceut Engn, Shanghai 200237, Peoples R China;[2]Chinese Acad Sci, Shanghai Inst Organ Chem, Shanghai 200032, Peoples R China

年份：2004

卷号：15

期号：15

起止页码：2327

外文期刊名：TETRAHEDRON-ASYMMETRY

收录：;WOS:【SCI-EXPANDED(收录号:WOS:000223360500005)，CCR-EXPANDED(收录号:WOS:000223360500005)】；

语种：英文

摘要：The asymmetric synthesis of (1S,6R,7S,9R)-7,9-bis(tert-butyldiphenylsilyloxy)-3-oxabicyclo[4,3,0]nonan-2-one 1 from (4S)-4-acetoxy-2-methoxycarbonyl-3-methoxycarbonylmethyl-2-cyclopenten-1-one 2 is described in eight steps. Compound 2 was readily prepared from L-malic acid according to a known procedure. The key step of this synthesis is a palladium on charcoal catalyzed hydrogenation of olefinic bicyclic lactone 9. (C) 2004 Elsevier Ltd. All rights reserved.