文献类型：期刊文献

英文题名：Efficient synthesis of kaempferol 3,7-O-bisglycosides via successive glycosylation with glycosyl ortho-alkynylbenzoates and trifluoroacetimidates

作者：Yang, Weizhun[1,2];Sun, Jiansong[1];Yang, Zhongyi[1];Han, Wei[2];Zhang, Wei-Dong[3];Yu, Biao[1]

机构：[1]Chinese Acad Sci, Shanghai Inst Organ Chem, State Key Lab Bioorgan & Nat Prod Chem, Shanghai 200032, Peoples R China;[2]E China Univ Sci & Technol, Sch Pharm, Shanghai 200237, Peoples R China;[3]Second Mil Med Univ, Sch Pharm, Dept Phytochem, Shanghai 200433, Peoples R China

年份：2012

卷号：53

期号：22

起止页码：2773

外文期刊名：TETRAHEDRON LETTERS

收录：;WOS:【SCI-EXPANDED(收录号:WOS:000303953200026)，CCR-EXPANDED(收录号:WOS:000303953200026)】；

基金：Financial support from the National Major Project of China (Grants 2009ZX09311-001 and 2008ZXJ09004-007) and the National Natural Science Foundation of China (20921091 and 20621062) are gratefully acknowledged.

语种：英文

外文关键词：Selective glycosylation; Kaempferol; Glycosyl ortho-alkynylbenzoate; Glycosyl trifluoroacetimidate

摘要：Selective glycosylation of the 3-OH of 5,4'-di-O-acetyl-kaempferol was achieved with glycosyl orthoalkynylbenzoates as donors under the catalysis of Ph(3)PALINTf(2), and subsequent glycosylation of the remaining 7-OH with glycosyl trifluoroacetimidates under the catalysis of BF3.OEt2, after global deprotection, afforded the kaempferol 3,7-O-bisglycosides conveniently. (C) 2012 Elsevier Ltd. All rights reserved.