文献类型：期刊文献

英文题名：Heterochiral β-Peptide Polymers Combating Multidrug-Resistant Cancers Effectively without Inducing Drug Resistance

作者：Shao, Ning[1];Yuan, Ling[2];Ma, Pengcheng[2];Zhou, Min[1];Xiao, Ximian[2];Cong, Zihao[2];Wu, Yueming[2];Xiao, Guohui[3];Fei, Jian[3];Liu, Runhui[1,2]

机构：[1]East China Univ Sci & Technol, State Key Lab Bioreactor Engn, Shanghai 200237, Peoples R China;[2]East China Univ Sci & Technol, Frontiers Sci Ctr Materiobiol & Dynam Chem, Key Lab Ultrafine Mat,Shanghai Frontiers Sci Ctr, Res Ctr Biomed Mat,Minist Educ,Sch Mat Sci & Engn, Shanghai 200237, Peoples R China;[3]Shanghai Jiao Tong Univ, Ruijin Hosp, Dept Gen Surg, Sch Med, Shanghai 200025, Peoples R China

年份：2022

卷号：144

期号：16

起止页码：7283

外文期刊名：JOURNAL OF THE AMERICAN CHEMICAL SOCIETY

收录：;EI(收录号：20221712025367);WOS:【SCI-EXPANDED(收录号:WOS:000799141600030)】；

基金：This research was supported by the National Natural Science Foundation of China for Innovative Research Groups (no. 51621002), Program of Shanghai Academic/Technology Research Leader (20XD1421400), Shanghai Frontiers Science Center of Optogenetic Techniques for Cell Metabolism (Shanghai Municipal Education Commission), Research program of State Key Laboratory of Bioreactor Engineering, and the Fundamental Research Funds for the Central Universities (JKD01211520). The authors thank Research Center of Analysis and Test of East China University of Science and Technology for the help on the characterization. We also thank the staff members of the Mass Spectrometry System at the National Facility for Protein Science in Shanghai (NFPS), Zhangjiang Lab, China, for providing technical support and assistance in data collection and analysis.

语种：英文

外文关键词：Diseases - Biocompatibility - Cancer cells - Tumors

摘要：Multidrug resistance to chemotherapeutic drugs is one of the major causes for the failure of cancer treatment. Therefore, there is an urgent need to develop anticancer agents that can combat multidrug-resistant cancers effectively and mitigate drug resistance. Here, we report a rational design of anticancer heterochiral beta-peptide polymers as synthetic mimics of host defense peptides to combat multidrug-resistant cancers. The optimal polymer shows potent and broad-spectrum anticancer activities against multidrug-resistant cancer cells and is insusceptible to anticancer drug resistance owing to its membrane-damaging mechanism. The in vivo study indicates that the optimal polymer efficiently inhibits the growth and distant transfer of solid tumors and the metastasis and seeding of circulating tumor cells. Moreover, the polymer shows excellent biocompatibility during anticancer treatment on animals. In addition, the beta-peptide polymers address those prominent shortcomings of anticancer peptides and have superior stability against proteolysis, easy synthesis in large scale, and low cost. Collectively, the structural diversity and superior anticancer performance of beta-peptide polymers imply an effective strategy in designing and finding anticancer agents to combat multidrug-resistant cancers effectively while mitigating drug resistance.