文献类型：期刊文献

中文题名：Remote regioselective organocatalytic asymmetric [3+2] cycloaddition of N-2,2,2-trifluoroethyl isatin ketimines with cyclic 2,4-dienones

英文题名：Remote regioselective organocatalytic asymmetric [3+2] cycloaddition of N-2,2,2-trifluoroethyl isatin ketimines with cyclic 2,4-dienones

作者：Chuncheng Zou[1,2];Yuanyuan Han[1];Chuikun Zeng[1];Tony YZhang[1];Jinxing Ye[1];Gonghua Song[2]

机构：[1]Engineering Research Center of Pharmaceutical Process Chemistry,Ministry of Education,East China University of Science and Technology,Shanghai 200237,China;[2]Shanghai Key Laboratory of Chemistry Biology,East China University of Science and Technology,Shanghai 200237,China

年份：2020

卷号：31

期号：2

起止页码：377

中文期刊名：Chinese Chemical Letters

外文期刊名：中国化学快报（英文版）

收录：CSTPCD;;Scopus;CSCD:【CSCD2019_2020】；

基金：supported by the National Natural Science Foundation of China(Nos.21272068,21572056,21801077);China Postdoctoral Science Foundation(Nos.2017M621382,2018T110355);Shanghai Sailing Program(No.18YF1406200);the Fundamental Research Funds for the Central Universities。

语种：英文

中文关键词：Organocatalysis;Spiro;oxindole;skeleton;[3+2]cycloaddition;Cyclic;2,4-dienones;CF3;group

外文关键词：Organocatalysis;Spiro oxindole skeleton;[3+2] cycloaddition;Cyclic 2,4-dienones;CF3 group

摘要：An organocatalytic asymmetric [3+2] cycloaddition of trifluoromethyl-containing azomethine ylides with cyclic 2,4-dienones was developed.The process enables efficient incorporation of CF3 groups into functionalized spiro [pyrro lid in-3,2'-oxindoles] in high yields with good to excellent enantio-and diastereoselectivities.
An organocatalytic asymmetric [3+2] cycloaddition of trifluoromethyl-containing azomethine ylides with cyclic 2,4-dienones was developed.The process enables efficient incorporation of CF3 groups into functionalized spiro [pyrro lid in-3,2’-oxindoles] in high yields with good to excellent enantio-and diastereoselectivities.