文献类型：期刊文献

英文题名：Self-Assembled 2D Glycoclusters for the Targeted Delivery of Theranostic Agents to Triple-Negative Breast Cancer Cells

作者：Hu, Xi-Le[1,2];Ca, Quanyu[4];Gao, Jie[1,2,3];Field, Robert A.[5];Chen, Guo-Rong[1,2];Jia, Ningyang[4];Zang, Yi[3];Li, Jia[3];He, Xiao-Peng[1,2]

机构：[1]East China Univ Sci & Technol, Sch Chem & Mol Engn, Key Lab Adv Mat, Shanghai 200237, Peoples R China;[2]East China Univ Sci & Technol, Sch Chem & Mol Engn, Feringa Nobel Prize Scientist Joint Res Ctr, Shanghai 200237, Peoples R China;[3]Chinese Acad Sci, Shanghai Inst Mat Med, State Key Lab Drug Res, Natl Ctr Drug Screening, 189 Guo Shoujing Rd, Shanghai 201203, Peoples R China;[4]Eastern Hepatobiliary Surg Hosp, Dept Radiol, Shanghai 200438, Peoples R China;[5]John Innes Ctr, Dept Biol Chem, Norwich Res Pk, Norwich NR4 7UH, Norfolk, England

年份：2019

卷号：11

期号：25

起止页码：22181

外文期刊名：ACS APPLIED MATERIALS & INTERFACES

收录：;EI(收录号：20192607115266);WOS:【SCI-EXPANDED(收录号:WOS:000473251100014)】；

基金：This research is supported by the National Natural Science Foundation of China (21722801, 21776078, 81671739, 81673489, and 81125023), the Shanghai Municipal Science and Technology Major Project (Grant no. 2018SHZDZX03), and the International Cooperation Project (No. 16430724100). Ya-Wen Cheng is thanked for her help in compound synthesis and spectroscopic measurements.

语种：英文

外文关键词：self-assembly; 2D material; glycocluster; theranostics; breast cancer

摘要：Triple-negative breast cancer (TNBC) is a devastating disease worldwide, for which targeted imaging and therapeutic agents remain elusive. There has been growing awareness that carbohydrates are valuable as drug candidates and targeting agents for a variety of human diseases, including cancers that overexpress carbohydrate receptors on the cell surface. Here, we develop a two-dimensional (2D) glycocluster by means of simple, stepwise self assembly for the targeted delivery of theranostic agents to TNBC cells that express mannose receptors (MRs) on the cell surface. Human serum albumin, which contains a variety of hydrophobic pockets capable of accommodating small molecules, was used to simultaneously encapsulate a mannose-based glycoprobe and a commercial photosensitizer (i.e., Ce6). The multicomponent "neoglycoprotein" formed was used to self-assemble with 2D MnO2, producing 2D glycoclusters, which could be selectively internalized by a TNBC cell line (MDA-MB-231) as facilitated by binding to the transmembrane MR. The intracellular degradation of the 2D MnO2 backbone by biothiols then released Ce6 for cell imaging and, subsequently, photodynamic therapy. This study provides insights into the development of carbohydrate-based materials for targeted, stimuli-responsive theranostics of TNBC.