文献类型：期刊文献

英文题名：Hsa_circ_0033155: A potential novel biomarker for non-small cell lung cancer

作者：Gu, Xiaohua[1];Wang, Gang[2];Shen, Hui[1];Fei, Xiaoyun[1]

机构：[1]Shanghai Jiao Tong Univ, Dept Resp Med, Affiliated Peoples Hosp 6, 600 Yishan Rd, Shanghai 200233, Peoples R China;[2]East China Univ Sci & Technol, Sch Biotechnol, State Key Lab Bioreactor Engn, Shanghai 200237, Peoples R China

年份：2018

卷号：16

期号：4

起止页码：3220

外文期刊名：EXPERIMENTAL AND THERAPEUTIC MEDICINE

收录：;WOS:【SCI-EXPANDED(收录号:WOS:000444988800058)】；

基金：The present study was financially supported by National Natural Science Foundation of China (grant no. 81673014).

语种：英文

外文关键词：circular RNA; biomarker; hsa_circ_0033155; phosphatase and tensin homolog deleted on chromosome 10; non-small cell lung cancer

摘要：Circular RNAs (circRNAs) are a novel type of endogenous RNAs and increasing evidence have uncovered the important role of circRNA in tumor progression; however, the function of circRNAs in non-small cell lung cancer (NSCLC) remains largely unclear. In the present study, it was demonstrated that the expression level of hsa_circ_0033155 was significantly downregulated in NSCLC tissue and the expression of hsa_circ_0033155 correlated with lymphatic metastasis. In order to further investigate the possible role of hsa_circ_0033155 in NSCLC progression, circRNA was overexpressed in NSCLC cells and it was observed that the overexpression of hsa_circ_0033155 significantly decreased cell proliferation, colony formation and migration, and elevated the level of phosphatase and tensin homolog deleted on chromosome 10, a tumor suppressor in many types of tumor. In conclusion, hsa_circ_0033155 may serve as a prospective biomarker for detection and a promising therapeutic target for NSCLC.