文献类型：期刊文献

英文题名：Promoter-Controlled Synthesis and Antigenic Evaluation of Mannuronic Acid Alginate Glycans of Pseudomonas aeruginosa

作者：Zhang, Liangliang[1];Zhang, Yiyue[1];Hua, Qingting[1];Xu, Tong[1];Liu, Junru[1];Zhu, Yirong[1];Yang, You[1]

机构：[1]East China Univ Sci & Technol, Shanghai Frontiers Sci Ctr Optogenet Tech Cell Met, Engn Res Ctr Pharmaceut Proc Chem, Minist Educ,Sch Pharm,Shanghai Key Lab New Drug De, Shanghai 200237, Peoples R China

年份：2022

卷号：24

期号：45

起止页码：8381

外文期刊名：ORGANIC LETTERS

收录：;WOS:【SCI-EXPANDED(收录号:WOS:000883702300001)】；

基金：? ACKNOWLEDGMENTS Financial support from the National Natural Science Foundation of China (21871081 and 22071054) , the Shanghai Frontiers Science Center of Optogenetic Techniques for Cell Metabolism (Shanghai Municipal Education Commission) , and the First-Class Discipline Construction and Characteristic Development Guidance Funds for the Central Universities (SLC13223002) is gratefully acknowledged.

语种：英文

摘要：Pseudomonas aeruginosa is a leading cause of urinary tract, pulmonary, and wound infections and is becoming increasingly resistant to antibiotics. Here, we report the iodonium-and gold(I)promoted bimodal glycosylation of glycosyl (Z)-ynenoates for highly fi-selective promoter-controlled synthesis and antigenic evaluation of a series of 1,2-cis-fi-linked mannuronic acid alginate glycans of P. aeruginosa up to a 24-mer, which represents the longest polymannuronic acid synthesized to date. By screening the six synthetic mannuronic acid alginate glycans with the mouse serum antibodies, we identified the mannuronic acid tetrasaccharide as the optimal antigen epitope for the development of vaccines against P. aeruginosa.