文献类型：期刊文献

英文题名：Influences of mesoporous magnesium silicate on the hydrophilicity, degradability, mineralization and primary cell response to a wheat protein based biocomposite

作者：Feng, Shipeng[1,2];Li, Jianyou[3];Jiang, Xuesheng[3];Li, Xiongfeng[3];Pan, Yongkang[1,2];Zhao, Liming[1,2];Boccaccini, Aldo R.[4];Zheng, Kai[4];Yang, Lili[5];Wei, Jie[1,2]

机构：[1]East China Univ Sci & Technol, Key Lab Ultrafine Mat, Minist Educ, Shanghai 200237, Peoples R China;[2]East China Univ Sci & Technol, State Key Lab Bioreactor Engn, Shanghai 200237, Peoples R China;[3]Huzhou Cent Hosp, Dept Orthoped, 198 Hongqi Rd, Huzhou 313000, Peoples R China;[4]Univ Erlangen Nurnberg, Inst Biomat, Dept Mat Sci & Engn, Cauerstr 6, D-91058 Erlangen, Germany;[5]Second Mil Med Univ, Changzheng Hosp, Dept Orthopaed Surg, Shanghai 200003, Peoples R China

年份：2016

卷号：4

期号：39

起止页码：6428

外文期刊名：JOURNAL OF MATERIALS CHEMISTRY B

收录：;EI(收录号：20164202923261);WOS:【SCI-EXPANDED(收录号:WOS:000386863100005)】；

基金：This study was supported by grants from the National Natural Science Foundation of China (81271705, 81572194), the National High Technology Research & Development Program of China (863 Program) (no. 2014AA021202), the Major International Joint Research Project between China and Korea (81461148033), and the National Research Foundation of Korea (NRF) Grant (NRF-2014K2A2A7066637), and Zhejiang Provinical Natural Science Foundation of China (LY15E020001), Medical Scientific Research Foundation of Zhejiang Province (2014PYA021).

语种：英文

外文关键词：Bioactivity - Magnesium compounds - Sol-gels - Tissue regeneration - Bone - Silicates - Biodegradable polymers - Phosphate minerals - Hydrophilicity

摘要：A novel bioactive composite based on wheat protein (WP) and mesoporous magnesium silicate (m-MS) with a high specific surface area is presented in this study for potential bone tissue regeneration. Wheat protein (WP) is a type of a biodegradable natural polymer material. The m-MS was prepared by the sol gel technique, which was incorporated into WP to fabricate m-MS/WP composites. The increasing amount of m-MS improved the surface hydrophilicity of m-MS/WP composites. The results showed that the degradation ratio of the m-MS/WP composites increased with an increase in the m-MS content after it was soaked in a Tris-HCl solution for 12 weeks. Moreover, the m-MS/WP composites with 40 wt% m-MS content (WP40) were able to maintain a suitable pH value over a prolonged soaking time, which might be dependent on the content of the m-MS. The WP40 showed a good apatite formation ability after it was soaked in simulated body fluid (SBF) for 7 days, indicating good bioactivity. Moreover, the WP40 with cytocompatibility stimulated the attachment, proliferation and differentiation of MC3T3-E1 osteoblast cells. Briefly, the results indicated that WP40 had good bioactivity, degradability, cytocompatibility and osteogenesis and might be a new biomaterial for bone regeneration.