文献类型：期刊文献

英文题名：Characteristics, phase behavior and control release for copolymer-liposome with both pH and temperature sensitivities

作者：Zhou, Wenting[1];An, Xueqin[1];Wang, Junzhi[1];Shen, Weiguo[1];Chen, Zhiyun[1];Wang, Xiaoyong[1]

机构：[1]E China Univ Sci & Technol, Sch Chem & Mol Engn, Shanghai 200237, Peoples R China

年份：2012

卷号：395

起止页码：225

外文期刊名：COLLOIDS AND SURFACES A-PHYSICOCHEMICAL AND ENGINEERING ASPECTS

收录：;EI(收录号：20120314703238);WOS:【SCI-EXPANDED(收录号:WOS:000300206400032)】；

基金：This work is financially supported by the National Nature Science Foundation of China (20673059, 20573056 and 21073063), Nature Science Keystone Foundation of Shanghai (08jc1408100), Fundamental Research Funds for the Central Universities, China (No. WK0913002), and National High-tech Research and Development program of China (863 program No. 2011AA06A107).

语种：英文

外文关键词：pH-sensitive; Thermo-sensitive; Copolymer-liposome; Control release; Berberine hydrochloride

摘要：A pH- and thermo-sensitive berberine hydrochloride liposome modified by the poly(N-isopropylacrylamide-co-methacrylic acid-co-octadecyl acrylate) was synthesized. The morphology and size were determined by atomic force microscope (AFM) and dynamic light scattering (DLS). The phase transition temperature (T-pm) and phase transition pH (pH*) of the copolymer-liposome were obtained by differential scanning calorimetry (DSC). The results indicate that the size of copolymer-liposome depends on the mass ratios of the copolymer to soya bean lecithin (SPC) and the solution pH value, and the size can reach a maximum value at phase transition pH (pH*). The T-pm and pH* were affected by the mass ratios of the copolymer to SPC and properties of the copolymer. The release of berberine hydrochloride (BH) from the copolymer-liposome was investigated and the maximum release of BH was caused at T-pm and pH* of the copolymer-liposome. The results illustrate that BH released from the liposome is due to the phase transition of the copolymer-liposome, where both T-pm and pH* were acted as switches of the phase transition, and both spacial and temporal releases can be carried out by adjusting the temperature, pH value and release time. Crown Copyright (C) 2011 Published by Elsevier B.V. All rights reserved.