文献类型：期刊文献

英文题名：Recent Advances in Microfluidics-Based Chromatography-A Mini Review

作者：Bao, Bo[1,2];Wang, Zhichao[1,2];Thushara, Dilantha[3];Liyanage, Achini[3];Gunawardena, Sanja[3];Yang, Zaiyong[4];Zhao, Shuangliang[1,2,4]

机构：[1]East China Univ Sci & Technol, State Key Lab Chem Engn, Shanghai 200237, Peoples R China;[2]East China Univ Sci & Technol, Sch Chem Engn, Shanghai 200237, Peoples R China;[3]Univ Moratuwa, Dept Chem & Proc Engn, Moratuwa 10400, Sri Lanka;[4]Guangxi Univ, Guangxi Key Lab Petrochem Resource Proc & Proc In, Sch Chem & Chem Engn, Nanning 530004, Peoples R China

年份：2021

卷号：8

期号：1

外文期刊名：SEPARATIONS

收录：;WOS:【SCI-EXPANDED(收录号:WOS:000610733500001)】；

基金：This work is supported by National Natural Science Foundation of China (No. 21808056) and the Shanghai International Science and Technology Collaboration Program (No. 18160743700).

语种：英文

外文关键词：microfluidics; chromatography; on-chip; LC system

摘要：Microfluidics-based liquid chromatography is based on the miniaturization of the different types of liquid chromatography (LC) systems (e.g., affinity, adsorption, size exclusion, ion exchange) on a microchip to perform on-chip separation of different types of analytes. On-chip chromatography finds applications in genomics, proteomics, biomarker discovery, and environmental analysis. Microfluidics-based chromatography has good reproducibility and small sample consumption. However, the on-chip chromatography fabrication techniques are often more challenging to perform than conventional LC column preparation. Different research groups have attempted to develop different techniques to fabricate microfluidics-based LC systems. In this review, we will summarize the recent advances in microfluidics-based chromatography.